Center for Reproductive Medicine, Changzheng Hosptial, Second Military Medical University, Shanghai, China.
Shanghai Key Laboratory of Embryo Original Diseases, Center for Reproductive Medicine & Fertility Preservation Program, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Front Cell Infect Microbiol. 2021 Sep 16;11:649067. doi: 10.3389/fcimb.2021.649067. eCollection 2021.
The microbiota in the human body play critical roles in many physiological and pathological processes. However, the diversity and dynamics of the female genital tract (FGT) microbiota have not been fully unveiled. In this study, we characterized the microbiome variations in reproductive-aged Chinese women, and we revealed that the cervicovaginal microbiota were dominated by . Overall, the composition of microbiota in the uterine cavity was more diverse than that in the vagina and cervix. A positive correlation between and was observed in both the vagina and the cervix, suggesting that these two species might have a symbiotic relationship in the cervicovaginal microbiota. Moreover, we, for the first time, stratified the reproductive-aged Chinese women into subgroups, based on their microbiome profiles. Furthermore, we identified the bacteria whose abundance changed in the uterine cavity of infertile patients when compared with healthy controls, such as and . Functionally, the metabolism-related pathways, neurotrophin signaling pathway, and adipocytokine signaling pathway were predominantly dysregulated in the uterine cavity of infertile patients. In conclusion, we characterized a comprehensive microbial landscape in FGT, as well as their functional roles in female infertility of the Chinese population.
人体中的微生物群在许多生理和病理过程中起着关键作用。然而，女性生殖道（FGT）微生物群的多样性和动态尚未完全揭示。在这项研究中，我们描述了中国育龄妇女的微生物组变化，结果表明，宫颈阴道微生物群主要由 主导。总体而言，子宫腔中的微生物群落组成比阴道和宫颈更为多样化。在阴道和宫颈中均观察到 与 之间存在正相关，这表明这两个物种在宫颈阴道微生物群中可能具有共生关系。此外，我们首次根据微生物组特征将中国育龄妇女分为亚组。此外，我们还确定了与健康对照组相比，在不孕患者子宫腔中丰度发生变化的细菌，如 和 。功能上，代谢相关途径、神经营养因子信号通路和脂肪细胞因子信号通路在不孕患者的子宫腔中明显失调。总之，我们描述了 FGT 的全面微生物景观，以及它们在中国人群中女性不孕的功能作用。
