Pitchappan R, Muthukkaruppan V
J Exp Zool. 1977 Feb;199(2):177-88. doi: 10.1002/jez.1401990203.
This paper describes the distribution of thymus-derived lymphocytes in the spleen of the lizard, Calotes versicolor. Our studies reveal the existence of red and white pulp in the spleen. The red pulp consists of collagenous fibrous septae containing lymphocytes, erythrocytes and sinuses. The white pulp is an area enclosed by fibrous septae, containing lymphocytes, reticular cells and arterioles. The region around the arteriole in the white pulp was depleted of lymphocytes either one month after adult thymectomy or after anti-thymocyte serum treatment. The repopulation of this region was observed in sham-thymectomized controls, but not in thymectomized lizards. Therefore, this peri-arteriolar region may be designated as a thymus-dependent area, as described previously in higher vertebrates. The significance of these findings is discussed in relation to the phylogeny of the immune system.
本文描述了变色树蜥脾脏中胸腺衍生淋巴细胞的分布情况。我们的研究揭示了脾脏中存在红髓和白髓。红髓由含有淋巴细胞、红细胞和血窦的胶原纤维间隔组成。白髓是由纤维间隔包围的区域，含有淋巴细胞、网状细胞和小动脉。在成年胸腺切除术后一个月或抗胸腺细胞血清处理后，白髓中围绕小动脉的区域淋巴细胞减少。在假胸腺切除对照组中观察到该区域的再填充，但在胸腺切除的蜥蜴中未观察到。因此，如先前在高等脊椎动物中所描述的，这个小动脉周围区域可被指定为胸腺依赖区。本文结合免疫系统的系统发育对这些发现的意义进行了讨论。
