Rymaszewska J, Urbanska K M, Szczesniak D, Stanczykiewicz B, Trypka E, Zablocka A
Wroclaw Medical University, Department of Psychiatry, L. Pasteur 10, 50-367 Wroclaw, Poland.
Wroclaw Medical University, Department of Psychiatry, L. Pasteur 10, 50-367 Wroclaw, Poland
Cryo Letters. 2018 May/Jun;39(3):190-195.
Mild Cognitive Impairments (MCI) and dementia are still incurable. The Whole-Body Cryotherapy (WBC) - short, cyclic exposure to extremely low temperatures - has proven anti-inflammatory and anti-oxidative effects. It can also induce hormonal, lipid and neural changes.
To evaluate the WBC effect on cognitive functioning and blood parameters of MCI patients.
Participants with MCI undertook 10 WBC sessions. Cognitive functions and depressive symptoms were assessed before the first session, after the last session and 2 weeks later. Whole blood samples were collected.
The cognitive functioning improved after 10 WBC sessions (p<0.05), especially memory processes. WBC caused a significant (p<0.05) increase of NO plasma level, BDNF concentration (p<0.05) and reduction of IL-6 (p<0.05). The moderate relationship between NO and cognitive functioning was noticed after WBC.
The preliminary results of the first study evaluating WBC on memory deficits suggest that WBC may be useful as a supportive therapy of MCI.
轻度认知障碍（MCI）和痴呆症仍然无法治愈。全身冷冻疗法（WBC）——短时间、周期性暴露于极低温度下——已被证明具有抗炎和抗氧化作用。它还能引起激素、脂质和神经方面的变化。
评估全身冷冻疗法对MCI患者认知功能和血液参数的影响。
MCI参与者进行了10次全身冷冻疗法治疗。在第一次治疗前、最后一次治疗后及2周后评估认知功能和抑郁症状。采集全血样本。
10次全身冷冻疗法治疗后认知功能得到改善（p<0.05），尤其是记忆过程。全身冷冻疗法导致血浆NO水平显著升高（p<0.05）、脑源性神经营养因子浓度升高（p<0.05）以及白细胞介素-6水平降低（p<0.05）。全身冷冻疗法后观察到NO与认知功能之间存在中度相关性。
第一项评估全身冷冻疗法对记忆缺陷影响的研究的初步结果表明，全身冷冻疗法可能作为MCI的辅助治疗方法有用。
