Department of Pediatrics, College of Medicine, and Department of Landscape Architecture and Urban Planning, College of Architecture, Texas A&M University, College Station, TX
Mailman Center for Child Development, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL.
Diabetes Care. 2018 Oct;41(10):2064-2071. doi: 10.2337/dc17-2707. Epub 2018 Jul 30.
The objective of the study was to report on the measurement properties of the revised and updated Pediatric Quality of Life Inventory (PedsQL) 3.2 Diabetes Module for children, adolescents, and young adults with type 1 diabetes.
The 33-item PedsQL 3.2 Diabetes Module and PedsQL Generic Core Scales were completed in a 10-site national field test study by 656 families of patients ages 2-25 years with type 1 diabetes.
The 15-item Diabetes Symptoms Summary Score and 18-item Diabetes Management Summary Score were derived from the factor analysis of the items. The Diabetes Symptoms and Diabetes Management Summary Scores evidenced excellent reliability (patient self-report α = 0.88-0.90; parent proxy report α = 0.89-0.90). The Diabetes Symptoms and Diabetes Management Summary Scores demonstrated construct validity through medium to large effect size correlations with the Generic Core Scales Total Scale Score ( = 0.43-0.67, < 0.001). HbA was significantly correlated with the Diabetes Symptoms and Diabetes Management Summary Scores ( = -0.21 to -0.29, < 0.001). Minimal clinically important difference scores ranged from 5.05 to 5.55.
The PedsQL 3.2 Diabetes Module Diabetes Symptoms and Diabetes Management Summary Scores demonstrated excellent measurement properties and may be useful as standardized patient-reported outcomes of diabetes symptoms and diabetes management in clinical research, clinical trials, and practice in children, adolescents, and young adults with type 1 diabetes.
本研究旨在报告经过修订和更新的儿童生活质量量表（PedsQL）3.2 糖尿病模块的测量特性，该模块适用于 1 型糖尿病的儿童、青少年和年轻患者。
在一项涉及 10 个地点的全国现场测试研究中，656 个年龄在 2-25 岁的 1 型糖尿病患者家庭完成了 33 项 PedsQL 3.2 糖尿病模块和 PedsQL 通用核心量表。
从项目的因子分析中得出了 15 项糖尿病症状总结评分和 18 项糖尿病管理总结评分。糖尿病症状和糖尿病管理总结评分的可靠性非常高（患者自评α=0.88-0.90；家长代理报告α=0.89-0.90）。糖尿病症状和糖尿病管理总结评分通过与通用核心量表总分（=0.43-0.67，<0.001）中等至较大的效应大小相关性，证明了其结构有效性。HbA 与糖尿病症状和糖尿病管理总结评分显著相关（=0.21-0.29，<0.001）。最小临床重要差异评分范围为 5.05 至 5.55。
PedsQL 3.2 糖尿病模块的糖尿病症状和糖尿病管理总结评分具有优异的测量特性，可作为 1 型糖尿病儿童、青少年和年轻患者糖尿病症状和糖尿病管理的标准化患者报告结局，用于临床研究、临床试验和临床实践。
