Department of Microbiology, Medicinal Plant, Research Center of Barij, Kashan, Iran.
Department of Traditional Medicine, Research Center of Barij, Kashan, Iran.
Phytomedicine. 2018 Jul 15;46:69-77. doi: 10.1016/j.phymed.2018.04.018. Epub 2018 Apr 10.
N. sativa seeds is the source of fixed oil, which contain fatty acids and thymoquinone. N. sativa fixed oil topically or orally is used traditionally for management of pain in back, joints, musculoskeletal organs and arthritis rheumatoid.
The aim of this review article was to evaluate the potential effects of N. sativa fixed oil in pain and inflammation, especially in arthritis rheumatoid.
All information was extracted from accessible and inaccessible sources (books, electronic sources, thesis and etc.).
The results of our investigation showed N. sativa fixed oil, especially thymoquinone content had valuable anti-inflammatory and analgesic effects via different pathways. The efficacy of thymoquinone as potential treatment was confirmed in different animal model of arthritis and the clinical studies confirmed the oral (n = 4) and topical use (n = 1) of N. sativa fixed oil without adverse effects in patients suffering from arthritis rheumatoid.
The larger multicenter clinical trials for comparing the efficacy of topical, oral administrations and current treatment may help to understand better the efficacy of valuable fixed oil.
黑种草籽油是固定油的来源，其含有脂肪酸和百里醌。传统上，黑种草籽油无论是局部使用还是口服使用，都被用于治疗背部、关节、肌肉骨骼器官和类风湿性关节炎疼痛。
本文综述的目的是评估黑种草籽油在疼痛和炎症方面的潜在作用，特别是在类风湿性关节炎方面。
所有信息均从可及和不可及的来源（书籍、电子资源、论文等）中提取。
我们的研究结果表明，黑种草籽油，特别是百里醌含量，通过不同途径具有有价值的抗炎和镇痛作用。百里醌作为一种潜在的治疗方法，在不同的关节炎动物模型中得到了证实，临床研究证实，口服（n=4）和局部使用（n=1）黑种草籽油在类风湿性关节炎患者中无不良反应。
更大规模的多中心临床试验比较局部、口服给药和现有治疗方法的疗效，可能有助于更好地了解有价值的固定油的疗效。
