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Does rapamycin slow down time?

作者信息

Blagosklonny Mikhail V

机构信息

Mikhail V. Blagosklonny: Roswell Park Cancer Institute, Buffalo, NY, USA.

出版信息

Oncotarget. 2018 Jul 13;9(54):30210-30212. doi: 10.18632/oncotarget.25788.

DOI:10.18632/oncotarget.25788
PMID:30100983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6084391/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65fd/6084391/71de22512006/oncotarget-09-30210-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65fd/6084391/74e7a0f44b8f/oncotarget-09-30210-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65fd/6084391/71de22512006/oncotarget-09-30210-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65fd/6084391/74e7a0f44b8f/oncotarget-09-30210-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65fd/6084391/71de22512006/oncotarget-09-30210-g002.jpg

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本文引用的文献

1
A parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type .一种孤雌生殖准程序在野生型衰老过程中引发畸胎瘤样肿瘤。
NPJ Aging Mech Dis. 2018 Jun 13;4:6. doi: 10.1038/s41514-018-0025-3. eCollection 2018.
2
mTOR signaling regulates central and peripheral circadian clock function.mTOR 信号转导调节中枢和外周生物钟功能。
PLoS Genet. 2018 May 11;14(5):e1007369. doi: 10.1371/journal.pgen.1007369. eCollection 2018 May.
3
mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells.mTORC1 信号通路：糖尿病 β 细胞中的双刃剑。
Front Aging Neurosci. 2022 Dec 6;14:1048260. doi: 10.3389/fnagi.2022.1048260. eCollection 2022.
4
Atlos Labs and the quest for immortality: but can we live longer right now?阿特洛斯实验室与对永生的追求：但我们现在能活得更久吗？
Oncoscience. 2022 Apr 22;9:13-16. doi: 10.18632/oncoscience.552. eCollection 2022.
5
The hyperfunction theory: An emerging paradigm for the biology of aging.超功能理论：衰老生物学的新兴范式。
Ageing Res Rev. 2022 Feb;74:101557. doi: 10.1016/j.arr.2021.101557. Epub 2022 Jan 3.
6
The hoverfly and the wasp: A critique of the hallmarks of aging as a paradigm.食蚜蝇与黄蜂：对衰老作为范式的标志性特征的批判。
Ageing Res Rev. 2021 Sep;70:101407. doi: 10.1016/j.arr.2021.101407. Epub 2021 Jul 13.
7
Rapamycin Inhibits Glioma Cells Growth and Promotes Autophagy by miR-26a-5p/DAPK1 Axis.雷帕霉素通过miR-26a-5p/DAPK1轴抑制胶质瘤细胞生长并促进自噬。
Cancer Manag Res. 2021 Mar 22;13:2691-2700. doi: 10.2147/CMAR.S298468. eCollection 2021.
8
DNA- and telomere-damage does not limit lifespan: evidence from rapamycin.DNA 和端粒损伤并不限制寿命：来自雷帕霉素的证据。
Aging (Albany NY). 2021 Feb 12;13(3):3167-3175. doi: 10.18632/aging.202674.
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Rapamycin, proliferation and geroconversion to senescence.雷帕霉素、增殖和向衰老的衰老转化。
Cell Cycle. 2018;17(24):2655-2665. doi: 10.1080/15384101.2018.1554781. Epub 2018 Dec 12.
Cell Metab. 2018 Feb 6;27(2):314-331. doi: 10.1016/j.cmet.2017.11.004. Epub 2017 Dec 21.
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