Biotechnology Unit, University of Ribeirão Preto, SP, Av. Costábile Romano, 2201, Ribeirão Preto, SP, CEP 14096-900, Brazil.
Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.
Molecules. 2018 Aug 13;23(8):2018. doi: 10.3390/molecules23082018.
In the present investigation, -chalcone and licochalcone A were tested against MCF-7 and BT-20 breast cancer cell lines for anti-tumor activity. We found that both chalcones down regulated important genes associated to cancer development and inhibited cell migration of metastatic cells (BT-20). Finally, we observed that licochalcone A reduces the MDR-1 protein, while both chalcones suppress the AURKA protein in a dose-dependent manner. In conclusion, we observed the -chalcone and licochalcone A affected the cell viability of breast cancer cell lines MCF-7 and BT-20 and presents anti-metastatic and anti-resistance potential, by the repression of AUKA and MDR-1 proteins.
在本研究中，我们测试了查尔酮和甘草查尔酮 A 对 MCF-7 和 BT-20 乳腺癌细胞系的抗肿瘤活性。我们发现，这两种查尔酮都下调了与癌症发展相关的重要基因，并抑制了转移性细胞（BT-20）的迁移。最后，我们观察到甘草查尔酮 A 降低了 MDR-1 蛋白，而这两种查尔酮均以剂量依赖的方式抑制 AURKA 蛋白。总之，我们观察到查尔酮和甘草查尔酮 A 通过抑制 AURKA 和 MDR-1 蛋白的表达，影响 MCF-7 和 BT-20 乳腺癌细胞系的细胞活力，表现出抗转移和抗耐药的潜力。
