Baba M, Shigeta S
Antiviral Res. 1987 Feb;7(2):99-107. doi: 10.1016/0166-3542(87)90025-8.
One of the plant extracts, glycyrrhizin (GL) was investigated for its antiviral action on varicella-zoster virus (VZV) in vitro. When human embryonic fibroblast (HEF) cells were treated with GL after inoculation of virus (post-treatment), the average 50%-inhibitory dose (ID50) for five VZV strains was 0.71 mM, and the selectivity index (ratio of ID50 for host-cell DNA synthesis to ID50 for VZV replication) was 30. GL was also effective against VZV replication when HEF cells were treated 24 h before the inoculation (pretreatment). Furthermore, at a concentration of 2.4 mM GL inactivated more than 99% of virus particles within 30 min at 37 degrees C. In combination with other anti-herpes drugs (acyclovir, adenine arabinoside, bromovinyldeoxyuridine, and phosphonoformate) or human native beta-interferon, GL had an additive or slightly synergistic effect on VZV replication. The mechanism of anti-VZV action is still unclear. We postulate that GL inhibits the penetration, uncoating or release of virus particles.
研究了一种植物提取物甘草甜素（GL）在体外对水痘-带状疱疹病毒（VZV）的抗病毒作用。当在接种病毒后（治疗后）用GL处理人胚成纤维细胞（HEF）时，五种VZV毒株的平均50%抑制剂量（ID50）为0.71 mM，选择性指数（宿主细胞DNA合成的ID50与VZV复制的ID50之比）为30。当在接种前24小时（预处理）用GL处理HEF细胞时，GL对VZV复制也有效。此外，在37℃下，2.4 mM的GL浓度在30分钟内可使99%以上的病毒颗粒失活。与其他抗疱疹药物（阿昔洛韦、阿糖腺苷、溴乙烯脱氧尿苷和膦甲酸）或人天然β-干扰素联合使用时，GL对VZV复制具有相加或轻微协同作用。抗VZV作用的机制仍不清楚。我们推测GL抑制病毒颗粒的穿透、脱壳或释放。
