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Synthesis and biological evaluation of rapamycin-derived, next generation small molecules.
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The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain.
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The FRB domain of mTOR: NMR solution structure and inhibitor design.
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Why Is Rapamycin Not a Rapalog?
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Elastin-based protein polymer nanoparticles carrying drug at both corona and core suppress tumor growth in vivo.
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Creating diverse target-binding surfaces on FKBP12: synthesis and evaluation of a rapamycin analogue library.
ACS Comb Sci. 2011 Sep 12;13(5):486-95. doi: 10.1021/co200057n. Epub 2011 Jul 28.

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Unraveling the therapeutic landscape of approved non-peptide macrocycles.
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Combined Deep Learning and Molecular Modeling Techniques on the Virtual Screening of New mTOR Inhibitors from the Thai Mushroom Database.
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Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease.
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In Silico Strategy for Targeting the mTOR Kinase at Rapamycin Binding Site by Small Molecules.
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Evaluation of NMU-Induced Breast Cancer Treated with Sirolimus and Sunitinib on Breast Cancer Growth.
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Intravesical delivery of rapamycin via folate-modified liposomes dispersed in thermo-reversible hydrogel.
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Rapamycin-inspired macrocycles with new target specificity.
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1
Twenty-five years of mTOR: Uncovering the link from nutrients to growth.
Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11818-11825. doi: 10.1073/pnas.1716173114. Epub 2017 Oct 25.
3
A Novel mTOR Inhibitor; Anthracimycin for the Treatment of Human Hepatocellular Carcinoma.
Anticancer Res. 2017 Jul;37(7):3397-3403. doi: 10.21873/anticanres.11706.
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4.4 Å Resolution Cryo-EM structure of human mTOR Complex 1.
Protein Cell. 2016 Dec;7(12):878-887. doi: 10.1007/s13238-016-0346-6. Epub 2016 Dec 1.
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Tor forms a dimer through an N-terminal helical solenoid with a complex topology.
Nat Commun. 2016 Apr 13;7:11016. doi: 10.1038/ncomms11016.
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Architecture of human mTOR complex 1.
Science. 2016 Jan 1;351(6268):48-52. doi: 10.1126/science.aaa3870. Epub 2015 Dec 17.
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Chemically induced dimerization: reversible and spatiotemporal control of protein function in cells.
Curr Opin Chem Biol. 2015 Oct;28:194-201. doi: 10.1016/j.cbpa.2015.09.003. Epub 2015 Sep 29.
8
Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115.
J Med Chem. 2015 Jul 23;58(14):5599-608. doi: 10.1021/acs.jmedchem.5b00627. Epub 2015 Jul 8.
9
Discovery of mammalian target of rapamycin (mTOR) kinase inhibitor CC-223.
J Med Chem. 2015 Jul 9;58(13):5323-33. doi: 10.1021/acs.jmedchem.5b00626. Epub 2015 Jun 26.
10
Light-cleavable rapamycin dimer as an optical trigger for protein dimerization.
Chem Commun (Camb). 2015 Apr 4;51(26):5702-5. doi: 10.1039/c4cc09442e.

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