Department of Restorative Dentistry, Medical University of Białystok, Białystok, Poland.
Medical University of Białystok and Private Dental Practice in Białystok, Białystok, Poland.
Oxid Med Cell Longev. 2018 Jul 4;2018:3732842. doi: 10.1155/2018/3732842. eCollection 2018.
Cadmium is one of the main chemical pollutants found in the daily environment of developed countries. Cigarettes are a significant source of that metal, which makes it important in terms of oral cavity health. The aim of this study was to determine if increased supply of zinc in chronic exposure to cadmium might protect the sublingual gland structure against oxidative damage. The experiment took 12 months and was conducted on 72 adult male rats. They were randomized into 9 groups. Eight groups received cadmium in drinking water (as CdCl) at 5 or 50 mg Cd/dm and/or zinc (as ZnCl) at 30 or 60 mg Zn/dm. The control group received regular water. In the sublingual gland of all animal groups, levels of oxidative parameters were measured. The oxidative stress index was calculated as a TOS/TAS ratio. Cadmium exposure at 5 mg and 50 mg Cd/dm induced oxidative stress in the sublingual glands of the rats. Cadmium reduced the TAS and GSH levels and increased LPO, HO, TOS, and OSI. In cadmium exposure conditions, increasing the supply of zinc by 79% or 151%, as compared to the standard dietary intake of this microelement, completely prevented the reduction of TAS and GSH levels and accumulation of LPO, HO, and TOS in the examined gland at both exposure levels to that metal. The outcome data confirm the protective effect of increased zinc intake on the sublingual gland tissue in chronic cadmium exposure.
镉是发达国家日常环境中主要的化学污染物之一。香烟是这种金属的重要来源，因此对口腔健康很重要。本研究旨在确定在慢性镉暴露中增加锌的供应是否可以保护舌下腺结构免受氧化损伤。该实验持续了 12 个月，共有 72 只成年雄性大鼠参与。它们被随机分为 9 组。其中 8 组通过饮用水（CdCl）摄入 5 或 50mg Cd/dm 的镉和/或 30 或 60mg Zn/dm 的锌。对照组则摄入常规饮用水。在所有动物组的舌下腺中，均测量了氧化参数的水平。氧化应激指数计算为 TOS/TAS 比值。5mg 和 50mg Cd/dm 的镉暴露会导致大鼠舌下腺发生氧化应激。镉降低了 TAS 和 GSH 的水平，增加了 LPO、HO、TOS 和 OSI。在镉暴露条件下，与该微量元素的标准饮食摄入量相比，将锌的供应量增加 79%或 151%，可以完全防止 TAS 和 GSH 水平的降低以及 LPO、HO 和 TOS 在两种金属暴露水平下在被检查的腺体中的积累。研究结果数据证实了增加锌摄入对慢性镉暴露下舌下腺组织的保护作用。
