Department of Spinal Surgery, Jining No. 1 People's Hospital, Jining, Shandong, China.
Ninth Department of Orthopedics, Fifth Hospital of Harbin, Harbin, Heilongjiang, China.
IUBMB Life. 2018 Nov;70(11):1115-1121. doi: 10.1002/iub.1922. Epub 2018 Aug 18.
SNHG20 is a novel lncRNA which has been showed to be overexpressed and functions as oncogenic lncRNA in several types of human cancer. The role of SNHG20 in osteosarcoma is still unknown. The purpose of our study was to identify the clinical value and biological function of SNHG20 in osteosarcoma. Our results indicated SNHG20 was overexpressed in osteosarcoma tissues and cell lines compared with paired non-tumor tissues and normal human osteoblast cell line, respectively. Moreover, we observed high-expression of SNHG20 was obviously associated with Enneking stage, distant metastasis, and histological grade. SNHG20 expression was negatively associated with overall survival, and high-expression of SNHG20 was an independent unfavorable prognostic factor in osteosarcoma patients. Furthermore, SNHG20 promoted osteosarcoma cell migration and invasion through modulating epithelial-mesenchymal transition -associated genes. In conclusion, SNHG20 is an independent unfavorable prognostic factor in osteosarcoma patients, and functions as an oncogenic lncRNA to modulate tumor cell migration and invasion. © 2018 IUBMB Life, 70(11):1115-1121, 2018.
SNHG20 是一种新型的长链非编码 RNA，已被证明在几种人类癌症中过表达并发挥致癌长链非编码 RNA 的作用。SNHG20 在骨肉瘤中的作用尚不清楚。本研究旨在确定 SNHG20 在骨肉瘤中的临床价值和生物学功能。我们的研究结果表明，与配对的非肿瘤组织和正常人成骨细胞系相比，SNHG20 在骨肉瘤组织和细胞系中表达上调。此外，我们观察到 SNHG20 的高表达与 Enneking 分期、远处转移和组织学分级明显相关。SNHG20 的表达与总生存率呈负相关，SNHG20 的高表达是骨肉瘤患者独立的不良预后因素。此外，SNHG20 通过调节上皮-间充质转化相关基因促进骨肉瘤细胞的迁移和侵袭。总之，SNHG20 是骨肉瘤患者独立的不良预后因素，作为一种致癌长链非编码 RNA 调节肿瘤细胞的迁移和侵袭。
