Antiangiogenic, wound healing and antioxidant activity of (Endophytic Fungus) isolated from seaweed (.

Endophytic fungi from marine seaweeds are the less studied group of organisms with vast medical applications. The aim of the present study was to evaluate antioxidant, antiangiogenic as well as wound healing potential of the endophytic fungus isolated from the seaweed . The morphological characters and the rDNA internal transcribed spacer sequence analysis (BLAST search in Gen Bank database) was used for the identification of endophytic fungus. The antioxidant potential of the ethyl acetate extract of endophytic fungus was assessed by, 1,1-diphenyl-2-picryl-hydrazyl radical scavenging method. The fungal extract was also analysed for reducing power, total phenolic and flavonoid content. Antiangiogenic activity of the fungal extract was studied by inhibition of wound healing scratch assay and by Chick chorioallantoic membrane assay. The endophytic fungus was identified as (Gen Bank ID - KT384175). The ethyl acetate extract of showed a significant antioxidant and angiosuppressive activity. The ESI-LC-MS analysis of the extract revealed the presence of wide range of secondary metabolites. Results suggest that C. extract could be exploited as a potential source for angiogenic modulators.