Division of Experimental Medicine, Department of Medicine, University of California-San Francisco.
J Infect Dis. 2018 Aug 14;218(suppl_1):S12-S15. doi: 10.1093/infdis/jiy264.
Translational research is often conceptualized with an implicit directionality, taking an idea generated in the laboratory (ie, the "bench") and applying it at the point of care (ie, the "bedside"). This role is often played by physician-scientists who work both in the laboratory and in the clinic. Less well appreciated is the valuable role a physician-scientist can play by using compelling observations from clinical research studies to guide basic scientists toward clinically important problems and even novel scientific concepts. The goal of this editorial is to highlight this often overlooked role that clinical-translational physician-scientists can play in translating observations at the bedside to efforts at the bench, highlighting their importance for scientific progress and discussing the type of research training and scientific environments that can help these individuals flourish. The importance of cohort studies and multidisciplinary team science in this context will also be highlighted.
转化研究通常被设想为具有一种隐含的方向性，即将实验室中产生的想法（即“ bench ”）应用于护理点（即“ bedside ”）。 医师科学家经常扮演这个角色，他们既在实验室工作，也在临床工作。 鲜为人知的是，医师科学家可以通过利用临床研究中令人信服的观察结果来指导基础科学家解决临床重要问题甚至新颖的科学概念，从而发挥宝贵的作用。 本社论的目的是强调临床转化医师科学家在将床边观察结果转化为实验台工作方面可以发挥的经常被忽视的作用，强调他们对科学进步的重要性，并讨论有助于这些人蓬勃发展的研究培训和科学环境类型。 还将强调在此背景下队列研究和多学科团队科学的重要性。
