MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China.
Macromolecular Chemistry II and Center for Colloids and Interfaces, University of Bayreuth, Universitätsstraße 30, 95440, Bayreuth, Germany.
Small. 2018 Sep;14(37):e1802420. doi: 10.1002/smll.201802420. Epub 2018 Aug 20.
Complete drug release and efficient drug retention are two critical factors in reversing drug resistance in cancer therapy. In this regard, polymeric micelles with an upper critical solution temperature (UCST) are designed as a new exploration to reverse drug resistance. The amphiphilic UCST-type block copolymers are used to encapsulate photothermal agent IR780 and doxorubicin (DOX) simultaneously. The integrated UCST-type drug nanocarriers show light-triggered multiple synergistic effects to reverse drug resistance and are expected to kill three birds with one stone: First, owing to the photothermal effect of IR780, the nanocarriers will be dissociated upon exposure to laser irradiation, leading to complete drug release. Second, the photothermal effect-induced hyperthermia is expected to avoid the efflux of DOX and realize efficient drug retention. Last but not least, photothermal ablation of cancer cells can be achieved after laser irradiation. Therefore, the UCST-type drug nanocarriers provide a new strategy in reversing drug resistance in cancer therapy.
完全释放药物和有效保留药物是逆转癌症治疗中药物耐药性的两个关键因素。在这方面，具有上临界溶解温度（UCST）的聚合物胶束被设计为逆转药物耐药性的新探索。两亲性 UCST 型嵌段共聚物被用于同时包封光热剂 IR780 和阿霉素（DOX）。这种整合的 UCST 型药物纳米载体表现出光触发的多重协同作用，以逆转药物耐药性，并有望一石三鸟：首先，由于 IR780 的光热效应，纳米载体在激光照射下会解离，导致完全释放药物。其次，光热效应诱导的热疗有望阻止 DOX 的外排，实现有效的药物保留。最后但同样重要的是，激光照射后可以实现癌细胞的光热消融。因此，UCST 型药物纳米载体为癌症治疗中逆转药物耐药性提供了一种新策略。
