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用于光热疗法治疗骨转移乳腺癌的近红外诱导负载IR780的聚乳酸-羟基乙酸共聚物纳米颗粒

Near-infrared-induced IR780-loaded PLGA nanoparticles for photothermal therapy to treat breast cancer metastasis in bones.

作者信息

Li Jingyi, Hu Huiyu, Jiang Zichao, Chen Sijie, Pan Yixiao, Guo Qi, Xing Qiqi, Jing Zhaocheng, Hu Yihe, Wang Long

机构信息

Department of Orthopedics, Xiangya Hospital, Central South University Changsha Hunan 410008 China

Department of General Surgery, Xiangya Hospital, Central South University Changsha Hunan 410008 China.

出版信息

RSC Adv. 2019 Nov 5;9(62):35976-35983. doi: 10.1039/c9ra05813c. eCollection 2019 Nov 4.

DOI:10.1039/c9ra05813c
PMID:35540567
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9074936/
Abstract

Nanodrug-based cancer therapy, especially when treating bone metastases, faces the problem of limited therapeutic efficacy. In this work, we reported a photothermally triggered nanomaterial based on IR780-entrapped poly-lactide--glycolide (PLGA) nanoparticles (IR780@PLGA NPs) for the photothermal therapy of bone metastases of breast cancer, in which IR780 converted light into heat to play a role in "burning" the tumors. Anti-tumor therapy studies showed the impressive effectiveness of IR780@PLGA NPs in the photothermal therapy (PTT) of bone metastases. As a result, the IR780@PLGA NPs show a great potential for controlling the bone metastases of breast cancer.

摘要

基于纳米药物的癌症治疗，尤其是在治疗骨转移时，面临着治疗效果有限的问题。在这项工作中，我们报道了一种基于包裹IR780的聚乳酸-乙醇酸共聚物（PLGA）纳米颗粒（IR780@PLGA NPs）的光热触发纳米材料，用于乳腺癌骨转移的光热治疗，其中IR780将光转化为热，在“灼烧”肿瘤中发挥作用。抗肿瘤治疗研究表明，IR780@PLGA NPs在骨转移的光热治疗（PTT）中具有令人印象深刻的效果。因此，IR780@PLGA NPs在控制乳腺癌骨转移方面显示出巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70e6/9074936/f5c7f82fd918/c9ra05813c-f10.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70e6/9074936/f5c7f82fd918/c9ra05813c-f10.jpg
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