Bristol Dental School , University of Bristol , Bristol BS1 2LY , U.K.
School of Materials , University of Manchester , Manchester M13 9PL , U.K.
ACS Appl Mater Interfaces. 2018 Sep 12;10(36):30191-30200. doi: 10.1021/acsami.8b10928. Epub 2018 Aug 31.
The poor osseointegration of Ti implant significantly compromise its application in load-bearing bone repair and replacement. Electrically bioactive coating inspirited from heterojunction on Ti implant can benefit osseointegration but cannot avoid the stress shielding effect between bone and implant. To resolve this conflict, hierarchically structured Ti implant with electrically bioactive SnO-TiO bilayered surface has been developed to enhance osseointegration. Benefiting from the electric cue offered by the built-in electrical field of SnO-TiO heterojunction and the topographic cue provided by the hierarchical surface structure to bone regeneration, the osteoblastic function of basic multicellular units around the implant is significantly improved. Because the individual TiO or SnO coating with uniform surface exhibits no electrical bioactivity, the effects of electric and topographic cues to osseointegration have been decoupled via the analysis of in vivo performance for the placed Ti implant with different surfaces. The developed Ti implant shows significantly improved osseointegration with excellent bone-implant contact, improved mineralization of extracellular matrix, and increased push-out force. These results suggest that the synergistic strategy of combing electrical bioactivity with hierarchical surface structure provides a new platform for developing advanced endosseous implants.
钛植入物的骨整合不良严重限制了其在承重骨修复和置换中的应用。受钛植入物异质结启发的电活性涂层有益于骨整合，但不能避免骨与植入物之间的应力屏蔽效应。为了解决这一矛盾，开发了具有电活性 SnO-TiO 双层表面的分层结构钛植入物，以增强骨整合。得益于 SnO-TiO 异质结内置电场提供的电信号和分层表面结构提供的骨再生地形信号，植入物周围基本多细胞单位的成骨功能得到显著改善。由于具有均匀表面的单个 TiO 或 SnO 涂层没有电活性，因此通过对具有不同表面的植入钛的体内性能分析，已经解耦了电和地形信号对骨整合的影响。所开发的钛植入物具有显著改善的骨整合，表现为骨-植入物接触良好、细胞外基质矿化程度提高和推出力增加。这些结果表明，将电活性与分层表面结构相结合的协同策略为开发先进的内植物提供了新的平台。
