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用SiON和SiONP表面涂层改性的阳极氧化钛的界面附着力和表面生物活性。

Interfacial adhesion and surface bioactivity of anodized titanium modified with SiON and SiONP surface coatings.

作者信息

Awad Kamal, Young Simon, Aswath Pranesh, Varanasi Venu

机构信息

Department of Materials Science and Engineering, College of Engineering, The University of Texas at Arlington, Arlington, TX 76019, USA.

Bone-Muscle Research Center, College of Nursing & Health Innovation, The University of Texas at Arlington, Arlington, TX 76019, USA.

出版信息

Surf Interfaces. 2022 Feb;28. doi: 10.1016/j.surfin.2021.101645. Epub 2021 Nov 28.

DOI:10.1016/j.surfin.2021.101645
PMID:35005303
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8741176/
Abstract

Titanium (Ti) surface modification via coating technologies (plasma spraying, electron-beam deposition) has been used to enhance bone-implant bonding by increasing the rate of hydroxyapatite (HA) formation, a property known as bioactivity. Regardless the enhancement in the surface activity, the high fabrication-temperature (> 600 °C) reduces coating-implant adhesion due to thermal expansion mismatch and reduces bioactivity due to increased crystallinity in the coating. Thus, amorphous surface coatings with strong Ti-substrate adhesion that can be fabricated at relatively low temperatures are crucially needed for enhanced osseointegration. Therefore, this study aimed to enhance the Ti surface bioactivity via strongly adherent bioactive thin film coatings deposited by low temperature (< 400 °C) plasma enhanced chemical vapor deposition technique on nanopore anodized-Ti (A-Ti) surface. Two groups of coating (silicon oxynitride (SiON) and silicon oxynitrophosphide (SiONP)) were deposited on anodized Ti and tested for interfacial adhesion and surface bioactivity. TEM and XPS were used to investigate the interfacial composition while interfacial adhesion was tested using nano-indentation tests which indicated a strong interfacial adhesion between the coatings and the A-Ti substrate. Surface bioactivity of the modified Ti was tested by comprehensive surface characterization (i.e., chemical composition, surface energy, morphology, and mechanical properties) and apatite formation on each surface. SiONP coating significantly enhanced the Ti surface bioactivity that presented the highest surface coverage of carbonated hydroxyapatite (HCA, ~ 40%) with a Ca/P ratio (~ 1.65) close to the stoichiometric hydroxyapatite (~ 1.67) found in bone biomineral. The HCA structure and morphology were confirmed by HR-TEM/SAED, XRD, FT-IR, and HR-SEM/EDX. MSCs studies indicated preferable cells adhesion and proliferation on the modified surfaces without any cytotoxic effects. This study concluded that the improved surface bioactivity of Ti-SiON and Ti-SiONP coatings suggests their potential use as strongly adherent bioactive surface coatings for Ti implants.

摘要

通过涂层技术（等离子喷涂、电子束沉积）对钛（Ti）表面进行改性，已被用于通过提高羟基磷灰石（HA）的形成速率来增强骨-植入物结合，这一特性被称为生物活性。尽管表面活性有所增强，但由于热膨胀失配，较高的制造温度（>600°C）会降低涂层与植入物之间的附着力，并且由于涂层中结晶度增加而降低生物活性。因此，迫切需要能够在相对较低温度下制造的、具有强Ti基体附着力的非晶表面涂层，以增强骨整合。因此，本研究旨在通过低温（<400°C）等离子体增强化学气相沉积技术在纳米孔阳极氧化Ti（A-Ti）表面沉积强附着力的生物活性薄膜涂层，来提高Ti表面的生物活性。两组涂层（氮氧化硅（SiON）和氮氧化磷硅（SiONP））沉积在阳极氧化Ti上，并测试其界面附着力和表面生物活性。使用透射电子显微镜（TEM）和X射线光电子能谱（XPS）研究界面组成，同时使用纳米压痕试验测试界面附着力，结果表明涂层与A-Ti基体之间具有很强的界面附着力。通过综合表面表征（即化学成分、表面能、形态和力学性能）以及每个表面上磷灰石的形成，测试改性Ti的表面生物活性。SiONP涂层显著提高了Ti表面的生物活性，其呈现出最高的碳酸羟基磷灰石（HCA，40%）表面覆盖率，钙磷比（1.65）接近骨生物矿物中化学计量的羟基磷灰石（~1.67）。通过高分辨率透射电子显微镜/选区电子衍射（HR-TEM/SAED）、X射线衍射（XRD）、傅里叶变换红外光谱（FT-IR）和高分辨率扫描电子显微镜/能谱仪（HR-SEM/EDX）对HCA的结构和形态进行了确认。间充质干细胞（MSCs）研究表明，在改性表面上细胞具有良好的粘附和增殖能力，且无任何细胞毒性作用。本研究得出结论，Ti-SiON和Ti-SiONP涂层表面生物活性的改善表明它们有潜力作为Ti植入物的强附着力生物活性表面涂层。

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