单纯疱疹病毒纯化糖蛋白gB的免疫原性
Immunogenicity of purified glycoprotein gB of herpes simplex virus.
作者信息
Kino Y, Eto T, Nishiyama K, Ohtomo N, Mori R
出版信息
Arch Virol. 1986;89(1-4):69-80. doi: 10.1007/BF01309880.
PMID:3013134
Abstract
The efficacy of a herpes simplex virus (HSV) component vaccine consisting of viral glycoprotein gB was examined in a mouse system. Immunization of mice with HSV type 1 (HSV-1) gB emulsified in Freund's complete adjuvant or with HSV-1 gB adsorbed to aluminum gel was fully protective against subsequent challenge with HSV-1 or HSV type 2. Latent infection in the trigeminal ganglion was also prevented by immunization with gB.
摘要
在小鼠系统中检测了由病毒糖蛋白gB组成的单纯疱疹病毒（HSV）组分疫苗的效力。用弗氏完全佐剂乳化的1型单纯疱疹病毒（HSV-1）gB或吸附于铝胶的HSV-1 gB免疫小鼠，可使其完全抵御随后的HSV-1或2型单纯疱疹病毒攻击。用gB免疫还可预防三叉神经节中的潜伏感染。
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