Cappel R, Sprecher S, Rickaert F, de Cuyper F
Arch Virol. 1982;73(1):61-7. doi: 10.1007/BF01341728.
A DNA-free subunit herpes simplex virus (HSV) vaccine was administered to 15 volunteers without past evidence of HSV infection and to 25 patients with severe recurrent HSV infection. The immune response to the vaccine in these patients was compared to the immunological status of 20 non-vaccinated control patients with recurrent HSV infection. The vaccine elicited antibody and cell-mediated immunity (CMI) in the 15 subjects without past evidence of HSV infection and this response was similar to that observed after a natural infection. Among the 25 patients who were suffering from recurrent HSV infection the vaccine elicited complement dependent cytotoxic antibodies in 13 of these patients who did not possess these antibodies and increased significantly the titers of these antibodies in the 12 other patients. The vaccine gave a significant increase of the titers of the other specific antibodies as well as the level of cell-mediated immunity. The increase of the immunity level in these latter patient was not due to normal variations since in the non-vaccinated control group the antibody titers and CMI remained stable during the same period of time.
一种不含DNA的单纯疱疹病毒（HSV）亚单位疫苗被给予15名既往无HSV感染证据的志愿者以及25名患有严重复发性HSV感染的患者。将这些患者对疫苗的免疫反应与20名患有复发性HSV感染的未接种疫苗的对照患者的免疫状态进行比较。该疫苗在15名既往无HSV感染证据的受试者中引发了抗体和细胞介导免疫（CMI），这种反应与自然感染后观察到的反应相似。在25名患有复发性HSV感染的患者中，该疫苗在13名原本不具备补体依赖性细胞毒性抗体的患者中引发了此类抗体，并使另外12名患者的这些抗体滴度显著升高。该疫苗还使其他特异性抗体的滴度以及细胞介导免疫水平显著提高。后一组患者免疫水平的提高并非由于正常波动，因为在未接种疫苗的对照组中，抗体滴度和CMI在同一时期保持稳定。
