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在人肿瘤异种移植存在的情况下小鼠成纤维细胞的体内恶性转化。

The in vivo malignant transformation of mouse fibroblasts in the presence of human tumour xenografts.

作者信息

Sparrow S, Jones M, Billington S, Stace B

出版信息

Br J Cancer. 1986 Jun;53(6):793-7. doi: 10.1038/bjc.1986.134.

DOI:10.1038/bjc.1986.134
PMID:3013267
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2001411/
Abstract

During the routine serial passage of over 30 human tumour xenografts in athymic (nu. nu.) mice over a period of 6 years the induction of murine fibrosarcomas at the site of transplantation has been observed on three occasions. In two cases it has been possible to follow the development of these tumours over successive transplant generations. These sarcomas had growth rates, tumour karyotypes and isoenzyme patterns which clearly distinguished them from the original human xenografts.

摘要

在6年时间里，对30多种人肿瘤异种移植瘤在无胸腺（nu/nu）小鼠体内进行常规连续传代的过程中，有三次在移植部位观察到诱导产生了鼠纤维肉瘤。在两例中，有可能追踪这些肿瘤在连续移植代次中的发展情况。这些肉瘤的生长速度、肿瘤核型和同工酶模式明显有别于原始的人异种移植瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/2001411/c70028c82028/brjcancer00530-0085-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/2001411/ecd9300c823e/brjcancer00530-0083-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/2001411/08e862fd379b/brjcancer00530-0083-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/2001411/f70fa8428637/brjcancer00530-0083-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/2001411/6cc654558386/brjcancer00530-0084-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/2001411/59cc77753a08/brjcancer00530-0084-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/2001411/50f4f1ea85d0/brjcancer00530-0084-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/2001411/c68f9b7d0901/brjcancer00530-0084-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/2001411/39f7ca9748fd/brjcancer00530-0084-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/2001411/c70028c82028/brjcancer00530-0085-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/2001411/ecd9300c823e/brjcancer00530-0083-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/2001411/08e862fd379b/brjcancer00530-0083-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/2001411/f70fa8428637/brjcancer00530-0083-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/2001411/6cc654558386/brjcancer00530-0084-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/2001411/59cc77753a08/brjcancer00530-0084-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/2001411/50f4f1ea85d0/brjcancer00530-0084-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/2001411/c68f9b7d0901/brjcancer00530-0084-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/2001411/39f7ca9748fd/brjcancer00530-0084-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd2/2001411/c70028c82028/brjcancer00530-0085-a.jpg

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Cancer Res. 1982 Jan;42(1):198-206.
3
Studies on mechanism of action of anti-tumor-promoting agents: their specificity in two-stage promotion.抗肿瘤促进剂作用机制的研究：其在两阶段促进过程中的特异性。
霍氏嗜温单胞菌耐热直接溶血素突变体的潜在抗肿瘤治疗应用。
Cancer Sci. 2015 Apr;106(4):447-54. doi: 10.1111/cas.12623. Epub 2015 Mar 10.
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Experimental research of host macrophage canceration induced by glioma stem progenitor cells.胶质瘤干祖细胞诱导宿主巨噬细胞癌变的实验研究
Mol Med Rep. 2015 Apr;11(4):2435-42. doi: 10.3892/mmr.2014.3032. Epub 2014 Dec 2.
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In-vivo fusion of human cancer and hamster stromal cells permanently transduces and transcribes human DNA.人类癌细胞与仓鼠基质细胞的体内融合可永久性转导并转录人类DNA。
PLoS One. 2014 Sep 26;9(9):e107927. doi: 10.1371/journal.pone.0107927. eCollection 2014.
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Human pontine glioma cells can induce murine tumors.人类脑桥胶质瘤细胞可诱发鼠类肿瘤。
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Real-time PCR-based assay to quantify the relative amount of human and mouse tissue present in tumor xenografts.基于实时 PCR 的方法来定量检测肿瘤异种移植物中人组织和鼠组织的相对含量。
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