系统性红斑狼疮、类风湿性关节炎和硬皮病患者淋巴细胞对有丝分裂原的反应性。
Lymphocyte reactivity to mitogens in subjects with systemic lupus erythematosus, rheumatoid arthritis and scleroderma.
作者信息
Horwitz D A, Garrett M A
出版信息
Clin Exp Immunol. 1977 Jan;27(1):92-9.
The mitogenic reactivity of lymphocytes from subjects with systemic lupus erythematosus, rheumatoid arthritis and scleroderma was studied. Cultures containing either unseparated or separated lymphocytes were stimulated with phytohaemagglutinin, Con A and pokeweed mitogen after inhibitory serum factors were eluted from the cell surface. Incorporation of [3H]thymidine in patient cultures was compared to that of normal controls. Greatly decreased reactivity was found in SLE to all three mitogens. Significantly decreased values to some mitogens was also observed in rheumatoid arthritis and scleroderma, but the defect was less severe. Cultures of study subjects contained significantly fewer small lymphocytes than normal controls and this finding explained at least in part the decreased mitogenic reactivity.
对系统性红斑狼疮、类风湿性关节炎和硬皮病患者淋巴细胞的促有丝分裂反应性进行了研究。在用植物血凝素、刀豆蛋白A和商陆有丝分裂原刺激之前，先从细胞表面洗脱抑制性血清因子，然后对含有未分离或已分离淋巴细胞的培养物进行刺激。将患者培养物中[3H]胸腺嘧啶核苷的掺入情况与正常对照进行比较。发现系统性红斑狼疮患者对所有三种有丝分裂原的反应性大幅降低。在类风湿性关节炎和硬皮病患者中也观察到对某些有丝分裂原的值显著降低，但缺陷程度较轻。研究对象的培养物中小淋巴细胞的数量明显少于正常对照，这一发现至少部分解释了促有丝分裂反应性的降低。
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