Yu D T, Clements P J, Pearson C M
Clin Exp Immunol. 1977 May;28(2):326-31.
Eight subjects ran on a treadmill at 8 miles per hr for 10 min. All developed lymphocytosis with predominant effect on the B cells. This was repeated 5 hr after receiving 60 mg of Prednisone. The lymphocytosis of both T and B cells were suppressed. When this was repeated 2 hr after receiving Prednisone, only lymphocytosis of the T subpopulation was suppressed. It was concluded that corticosteroid administration could suppress entry of lymphocytes into the circulation, with preponderant effect on the T subpopulation.
8名受试者在跑步机上以每小时8英里的速度跑10分钟。所有人都出现了淋巴细胞增多，主要影响B细胞。在接受60毫克泼尼松5小时后重复此操作。T细胞和B细胞的淋巴细胞增多均受到抑制。当在接受泼尼松2小时后重复此操作时，仅T亚群的淋巴细胞增多受到抑制。得出的结论是，给予皮质类固醇可抑制淋巴细胞进入循环，对T亚群有主要影响。
