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卵巢癌患者腹水的脂肪酸组成及花生四烯酸代谢产物

Fatty acid composition and arachidonic acid metabolites in ascitic fluid of patients with ovarian cancer.

作者信息

Punnonen R, Seppälä E, Punnonen K, Heinonen P K

出版信息

Prostaglandins Leukot Med. 1986 May;22(2):153-8. doi: 10.1016/0262-1746(86)90084-3.

DOI:10.1016/0262-1746(86)90084-3
PMID:3014559
Abstract

Fatty acid composition and arachidonic acid metabolites in ascitic fluids of patients with ovarian cancer were compared to those in the peritoneal fluids of patients with benign gynecologic conditions. Substantial amounts of PGE2, PGF2 alpha, TXB2, and leukotriene B4 were detected in the fluids of the both patient groups. In the group of the cancer patients the concentrations of TXB2 were slightly smaller than those in the control group. In the percentage amounts of the eicosanoid precursor fatty acids there could not be detected differences between these two groups. However, in the peritoneal fluids of the cancer patients the percentage amount of palmitoleic acid (16:1) was significantly higher than that in the control group.

摘要

将卵巢癌患者腹水的脂肪酸组成和花生四烯酸代谢物与良性妇科疾病患者的腹膜液进行了比较。在两组患者的液体中均检测到大量的前列腺素E2、前列腺素F2α、血栓素B2和白三烯B4。癌症患者组中血栓素B2的浓度略低于对照组。在类二十烷酸前体脂肪酸的百分比含量方面,这两组之间未检测到差异。然而,癌症患者腹膜液中棕榈油酸(16:1)的百分比含量显著高于对照组。

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