Khan Fazlurrahman, Khan Mohammad M, Kim Young-Mog
Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, Korea.
Chemical Sciences, Faculty of Science, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong, BE1410, Brunei Darussalam.
Curr Pharm Biotechnol. 2018;19(8):631-643. doi: 10.2174/1389201019666180828090052.
A novel strategy has been adapted to combat the threat caused by biofilm forming-pathogenic bacteria in our environments. It involves the synthesis of antibiofilm compounds biologically (metabolites from animals, microbes and plants) and chemically. As a result of extensive research, a significant number of antimicrobial compounds and biofilm inhibitors have been isolated and characterized from different biological and chemical sources. However, lots of limitations such as poor delivery, water-insolubility, stability, expulsion by efflux pumps, and the development of acquired resistance due to long-term exposure have been associated with these compounds.
Conjugation or encapsulation of these antibiofilm drugs with different biocompatible, biodegradable, chemically and thermally stable nanomaterials results in enhanced efficiency of biofilm inhibition.
This review article evaluates the current impact of antibiofilm drugs including its delivery, efficiency of blocking cell attachment and molecular mechanisms of action that is conjugated or encapsulated with different types of biocompatible nanomaterials. It will lead to a better understanding of the antibiofilm drugs and their role in combating biofilms. It will also open new doors for the application of immobilized antibiofilm drugs.
一种新策略已被采用，以应对我们环境中形成生物膜的致病细菌所造成的威胁。该策略涉及通过生物方式（来自动物、微生物和植物的代谢产物）和化学方式合成抗生物膜化合物。经过广泛研究，已从不同生物和化学来源分离并鉴定出大量抗菌化合物和生物膜抑制剂。然而，这些化合物存在许多局限性，如递送性差、水不溶性、稳定性问题、被外排泵排出以及长期暴露导致获得性耐药的产生。
将这些抗生物膜药物与不同的生物相容性、可生物降解、化学和热稳定的纳米材料进行共轭或封装，可提高生物膜抑制效率。
这篇综述文章评估了抗生物膜药物的当前影响，包括其递送、阻断细胞附着的效率以及与不同类型生物相容性纳米材料共轭或封装后的分子作用机制。这将有助于更好地理解抗生物膜药物及其在对抗生物膜中的作用。它还将为固定化抗生物膜药物的应用打开新的大门。
