Gumerova Nadiia I, Al-Sayed Emir, Krivosudský Lukáš, Čipčić-Paljetak Hana, Verbanac Donatella, Rompel Annette
Universität Wien, Fakultät für Chemie, Institut für Biophysikalische Chemie, Wien, Austria.
Center for Translational and Clinical Research, Croatian Center of Excellence for Reproductive and Regenerative Medicine, School of Medicine, University of Zagreb, Zagreb, Croatia.
Front Chem. 2018 Aug 14;6:336. doi: 10.3389/fchem.2018.00336. eCollection 2018.
The antibacterial activity of 29 different polyoxometalates (POMs) against was investigated by determination of the minimum inhibitory concentration (MIC). The Preyssler type polyoxotungstate (POT) [NaPWO] demonstrates the highest activity against (MIC = 1 μg/ml) among all tested POMs. Moreover, we show that the Dawson type based anions, [PWO], [(PO)MoO], [AsMoO], [HPWVO], and [AsWO] are selective on (MIC range of 2-8 μg/ml). Among the six tested Keggin type based POTs ([PWO], [HPCoWO], [HCoTiWO], [SiWO], [SbWO], [AsWO]), only the mono-substituted [HCoTiWO] showed MIC value comparable to those of the Dawson type group. Polyoxovanadates (POVs) and Anderson type POMs were inactive against within the tested concentration range (1-256 μg/ml). Four Dawson type POMs [PWO], [(PO)MoO], [AsMoO], [HPWVO] and the Preyssler POT [NaPWO] showed promising antibacterial activity against (MICs < 8 μg/ml) and were therefore tested against three additional bacteria, namely , and . The most potent antibacterial agent was [NaPWO], exhibiting the lowest MIC values of 16 μg/ml against and 8 μg/ml against . The three most active compounds ([NaPWO], [PWO], and [HPWVO]) show bacteriostatic effects in killing kinetics study against . We demonstrate, that POM activity is mainly depending on composition, shape, and size, but in the case of medium-size POTs (charge is more than -12 and number of addenda atoms is not being higher than 22) its activity correlates with the total net charge.
通过测定最低抑菌浓度（MIC），研究了29种不同的多金属氧酸盐（POMs）对[具体细菌名称未给出]的抗菌活性。在所有测试的POMs中，普雷兹勒型聚氧钨酸盐（POT）[NaPWO]对[具体细菌名称未给出]表现出最高活性（MIC = 1μg/ml）。此外，我们表明基于道森型的阴离子[PWO]、[(PO)MoO]、[AsMoO]、[HPWVO]和[AsWO]对[具体细菌名称未给出]具有选择性（MIC范围为2 - 8μg/ml）。在六种测试的基于凯吉恩型的POTs（[PWO]、[HPCoWO]、[HCoTiWO]、[SiWO]、[SbWO]、[AsWO]）中，只有单取代的[HCoTiWO]显示出与道森型组相当的MIC值。在测试浓度范围（1 - 256μg/ml）内，聚氧钒酸盐（POVs）和安德森型POMs对[具体细菌名称未给出]无活性。四种道森型POMs [PWO]、[(PO)MoO]、[AsMoO]、[HPWVO]和普雷兹勒POT [NaPWO]对[具体细菌名称未给出]表现出有前景的抗菌活性（MICs < 8μg/ml），因此对另外三种细菌，即[具体细菌名称未给出]、[具体细菌名称未给出]和[具体细菌名称未给出]进行了测试。最有效的抗菌剂是[NaPWO]，对[具体细菌名称未给出]的最低MIC值为16μg/ml，对[具体细菌名称未给出]为8μg/ml。三种最具活性的化合物（[NaPWO]、[PWO]和[HPWVO]）在针对[具体细菌名称未给出]的杀菌动力学研究中显示出抑菌作用。我们证明，POM的活性主要取决于组成、形状和大小，但对于中等尺寸的POTs（电荷大于 - 12且加成原子数不高于22），其活性与总净电荷相关。
