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1
Nucleotide sequence of the coding region of the mouse N-myc gene.小鼠N-myc基因编码区的核苷酸序列。
EMBO J. 1986 Jun;5(6):1215-9. doi: 10.1002/j.1460-2075.1986.tb04349.x.
2
Nucleotide sequence analysis of the chicken gene c-mil, the progenitor of the retroviral oncogene v-mil.鸡基因c-mil（逆转录病毒癌基因v-mil的前身）的核苷酸序列分析。
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Structure and expression of the murine L-myc gene.
EMBO J. 1987 Nov;6(11):3359-66. doi: 10.1002/j.1460-2075.1987.tb02657.x.
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Structure and expression of B-myc, a new member of the myc gene family.myc基因家族新成员B-myc的结构与表达
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Mouse and rat B-myc share amino acid sequence homology with the c-myc transcriptional activator domain and contain a B-myc specific carboxy terminal region.小鼠和大鼠的B - myc与c - myc转录激活域具有氨基酸序列同源性，并包含一个B - myc特异性的羧基末端区域。
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6
Nucleotide sequence of the first exon of the rat c-myc gene: proviral insertions in murine leukemia virus-induced lymphomas do not affect exon 1.大鼠c-myc基因第一个外显子的核苷酸序列：鼠白血病病毒诱导的淋巴瘤中的前病毒插入不影响外显子1。
Virology. 1988 May;164(1):55-63. doi: 10.1016/0042-6822(88)90619-8.
7
Nucleotide sequence analysis of the chicken c-myc gene reveals homologous and unique coding regions by comparison with the transforming gene of avian myelocytomatosis virus MC29, delta gag-myc.通过与禽骨髓细胞瘤病毒MC29的转化基因δgag-myc进行比较，鸡c-myc基因的核苷酸序列分析揭示了同源和独特的编码区域。
Proc Natl Acad Sci U S A. 1983 Apr;80(8):2146-50. doi: 10.1073/pnas.80.8.2146.
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Nature. 1983;303(5919):725-8. doi: 10.1038/303725a0.
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Extensive sequence homology of the goldfish ras gene to mammalian ras genes.金鱼ras基因与哺乳动物ras基因的广泛序列同源性。
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Nucleic Acids Res. 1985 Apr 11;13(7):2545-58. doi: 10.1093/nar/13.7.2545.

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Moloney murine leukemia virus-induced lymphomas in p53-deficient mice: overlapping pathways in tumor development?莫洛尼鼠白血病病毒诱导的p53基因缺陷小鼠淋巴瘤：肿瘤发生过程中的重叠途径？
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2
Expression of laminin gamma 1 cultured hepatocytes involves repeated CTC and GC elements in the LAMC1 promoter.层粘连蛋白γ1在培养的肝细胞中的表达涉及LAMC1启动子中的重复CTC和GC元件。
Biochem J. 1996 Feb 1;313 ( Pt 3)(Pt 3):745-52. doi: 10.1042/bj3130745.
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Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2.
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Subnuclear localization and antitransforming activity of N-myc:beta-galactosidase fusion proteins.N-myc：β-半乳糖苷酶融合蛋白的亚核定位及抗转化活性
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Sequence conservation in the protein coding and intron regions of the engrailed transcription unit.engrailed转录单元的蛋白质编码区和内含子区域中的序列保守性。
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6
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Mol Cell Biol. 1988 Aug;8(8):3168-74. doi: 10.1128/mcb.8.8.3168-3174.1988.
7
Two N-myc polypeptides with distinct amino termini encoded by the second and third exons of the gene.由该基因的第二和第三外显子编码的具有不同氨基末端的两种N-myc多肽。
Mol Cell Biol. 1989 Apr;9(4):1545-52. doi: 10.1128/mcb.9.4.1545-1552.1989.
8
N-myc is frequently activated by proviral insertion in MuLV-induced T cell lymphomas.在鼠白血病病毒（MuLV）诱导的T细胞淋巴瘤中，N-myc常因前病毒插入而被激活。
EMBO J. 1989 Jan;8(1):133-6. doi: 10.1002/j.1460-2075.1989.tb03357.x.
9
Isolation and characterization of s-myc, a member of the rat myc gene family.大鼠myc基因家族成员s-myc的分离与鉴定。
Proc Natl Acad Sci U S A. 1989 Dec;86(23):9144-8. doi: 10.1073/pnas.86.23.9144.
10
Insertional activation of N-myc by endogenous Moloney-like murine retrovirus sequences in macrophage cell lines derived from myeloma cell line-macrophage hybrids.源自骨髓瘤细胞系-巨噬细胞杂交体的巨噬细胞系中，内源性莫洛尼样鼠逆转录病毒序列对N-myc的插入激活。
Mol Cell Biol. 1989 Oct;9(10):4515-22. doi: 10.1128/mcb.9.10.4515-4522.1989.

本文引用的文献

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A catalogue of splice junction sequences.剪接连接序列目录。
Nucleic Acids Res. 1982 Jan 22;10(2):459-72. doi: 10.1093/nar/10.2.459.
2
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour.人类神经母细胞瘤细胞系和一个神经母细胞瘤肿瘤中存在与myc细胞癌基因同源性有限的扩增DNA。
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Expression and amplification of the N-myc gene in primary retinoblastoma.N-myc基因在原发性视网膜母细胞瘤中的表达与扩增
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4
Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage.未经治疗的人类神经母细胞瘤中N - myc的扩增与疾病晚期相关。
Science. 1984 Jun 8;224(4653):1121-4. doi: 10.1126/science.6719137.
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Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma.由于DNA扩增导致人类基因N-myc表达增强，可能促使神经母细胞瘤发生恶性进展。
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Specific DNA sequence amplification in human neuroblastoma cells.人类神经母细胞瘤细胞中的特定DNA序列扩增
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7
Expression of the amplified domain in human neuroblastoma cells.扩增结构域在人神经母细胞瘤细胞中的表达。
Mol Cell Biol. 1984 Nov;4(11):2370-80. doi: 10.1128/mcb.4.11.2370-2380.1984.
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Activated expression of the N-myc gene in human neuroblastomas and related tumors.N-myc基因在人类神经母细胞瘤及相关肿瘤中的激活表达。
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Nuclear localization and DNA binding properties of a protein expressed by human c-myc oncogene.人类c-myc癌基因所表达蛋白质的核定位及DNA结合特性
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10
Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma.伯基特淋巴瘤中易位的c-myc基因的核苷酸序列改变。
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小鼠N-myc基因编码区的核苷酸序列。

Nucleotide sequence of the coding region of the mouse N-myc gene.

作者信息

Taya Y, Mizusawa S, Nishimura S

出版信息

EMBO J. 1986 Jun;5(6):1215-9. doi: 10.1002/j.1460-2075.1986.tb04349.x.

DOI:10.1002/j.1460-2075.1986.tb04349.x
PMID:3015591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1166930/
Abstract

A genomic clone for the mouse N-myc gene was isolated and the total nucleotide sequence (4807 bp) of the two coding exons and an intron located between them was determined. The amino acid sequence of the N-myc protein was deduced from the DNA sequence. This protein is composed of 462 amino acids, slightly larger than human and mouse c-myc proteins, and is rich in proline like the c-myc protein. Comparison of the amino acid sequences of the mouse N-myc and c-myc proteins showed that conserved sequences are located in eight regions: four regions are in the N-terminal half of the N-myc protein and are separated from each other by regions poorly homologous to those of the c-myc protein, and the four others are located in the C-terminal half, throughout which certain homology exists. A remarkable sequence containing 13 successive acidic amino acids is present in one of the conserved regions located in the middle of the N-myc protein.

摘要

分离出了小鼠N - myc基因的一个基因组克隆，并确定了两个编码外显子及其之间一个内含子的总核苷酸序列（4807 bp）。从DNA序列推导了N - myc蛋白的氨基酸序列。该蛋白由462个氨基酸组成，比人和小鼠的c - myc蛋白略大，并且像c - myc蛋白一样富含脯氨酸。小鼠N - myc和c - myc蛋白氨基酸序列的比较表明，保守序列位于八个区域：四个区域在N - myc蛋白的N端一半，彼此被与c - myc蛋白同源性较差的区域隔开，另外四个位于C端一半，整个区域存在一定的同源性。在位于N - myc蛋白中部的一个保守区域中存在一个包含13个连续酸性氨基酸的显著序列。