小鼠N-myc基因编码区的核苷酸序列。
Nucleotide sequence of the coding region of the mouse N-myc gene.
作者信息
Taya Y, Mizusawa S, Nishimura S
出版信息
EMBO J. 1986 Jun;5(6):1215-9. doi: 10.1002/j.1460-2075.1986.tb04349.x.
Abstract
A genomic clone for the mouse N-myc gene was isolated and the total nucleotide sequence (4807 bp) of the two coding exons and an intron located between them was determined. The amino acid sequence of the N-myc protein was deduced from the DNA sequence. This protein is composed of 462 amino acids, slightly larger than human and mouse c-myc proteins, and is rich in proline like the c-myc protein. Comparison of the amino acid sequences of the mouse N-myc and c-myc proteins showed that conserved sequences are located in eight regions: four regions are in the N-terminal half of the N-myc protein and are separated from each other by regions poorly homologous to those of the c-myc protein, and the four others are located in the C-terminal half, throughout which certain homology exists. A remarkable sequence containing 13 successive acidic amino acids is present in one of the conserved regions located in the middle of the N-myc protein.
摘要
分离出了小鼠N - myc基因的一个基因组克隆，并确定了两个编码外显子及其之间一个内含子的总核苷酸序列（4807 bp）。从DNA序列推导了N - myc蛋白的氨基酸序列。该蛋白由462个氨基酸组成，比人和小鼠的c - myc蛋白略大，并且像c - myc蛋白一样富含脯氨酸。小鼠N - myc和c - myc蛋白氨基酸序列的比较表明，保守序列位于八个区域：四个区域在N - myc蛋白的N端一半，彼此被与c - myc蛋白同源性较差的区域隔开，另外四个位于C端一半，整个区域存在一定的同源性。在位于N - myc蛋白中部的一个保守区域中存在一个包含13个连续酸性氨基酸的显著序列。
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