Asadi-Lari Mohsen, Homaee-Shandiz Fatemeh, Esmaeili-Hesari Ali
Department of Epidemiology and Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Med J Islam Repub Iran. 2018 Apr 12;32:31. doi: 10.14196/mjiri.32.31. eCollection 2018.
Various treatments are used to prolong survival and improve quality of life (QOL). The purpose of this study was to assess the change in QOL scores in patients with Oesophagogastric (OG) cancer undergoing curative intent and palliative therapy. This was a mix-designed cohort study with a consecutive sampling of patients with OG cancer who underwent curative or palliative treatment regimens. The QOL, as a determinant of efficacy and impact of cancer care, was evaluated using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaires. QOL data were collected from the eligible subjects at three points of time. The repeated measurement test was used to compare the significance of change in scores. Overall, 149 patients (54.4% male, 61.1% curative intent, 52.3% esophageal, 37.6 % gastric, 10.1% OG junction cancer; with mean age 62 year) with OG cancer were eligible for inclusion in the study. Compared to the palliative group, the curative group was more likely to have an esophageal tumor site, Squamous Cell Carcinoma, and stage 2 (versus stomach, Adenocarcinoma, and stage 4 in the palliative group). In comparing the patients' functional, global health status, and cancer symptom, considering time, group of treatment, and their mutual effect the result indicated significant difference between the intervention groups. Most patients with Oesophagogastric cancer are diagnosed with an incurable form of the disease. Hence in absence of curative treatment, palliative therapy is the most effective therapy to maintain patient independency and relieve pain and symptom in order to improve their QOL. The present study has shown that palliative similar to curative intervention can improve the QOL in cancer patient especially in short term.
采用了各种治疗方法来延长生存期并改善生活质量（QOL）。本研究的目的是评估接受根治性治疗和姑息性治疗的食管胃癌（OG）患者QOL评分的变化。这是一项混合设计的队列研究，对接受根治性或姑息性治疗方案的OG癌患者进行连续抽样。作为癌症护理疗效和影响的决定因素，使用欧洲癌症研究与治疗组织生活质量问卷对QOL进行评估。在三个时间点从符合条件的受试者收集QOL数据。采用重复测量检验来比较评分变化的显著性。总体而言，149例OG癌患者（男性占54.4%，根治性治疗意向者占61.1%，食管癌患者占52.3%，胃癌患者占37.6%，OG交界癌患者占10.1%；平均年龄62岁）符合纳入本研究的条件。与姑息治疗组相比，根治性治疗组更有可能患有食管肿瘤部位、鳞状细胞癌和2期（而姑息治疗组为胃、腺癌和4期）。在比较患者的功能、整体健康状况和癌症症状时，考虑时间、治疗组及其相互作用，结果表明干预组之间存在显著差异。大多数食管胃癌患者被诊断为无法治愈的疾病形式。因此，在没有根治性治疗的情况下，姑息治疗是维持患者独立性、缓解疼痛和症状以改善其QOL的最有效治疗方法。本研究表明，与根治性干预类似，姑息治疗可以改善癌症患者的QOL，尤其是在短期内。
