病原体与内皮细胞的相互作用及固有和适应性免疫的诱导。
Pathogen interactions with endothelial cells and the induction of innate and adaptive immunity.
机构信息
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
出版信息
Eur J Immunol. 2018 Oct;48(10):1607-1620. doi: 10.1002/eji.201646789. Epub 2018 Sep 21.
Abstract
There are over 10 trillion endothelial cells (EC) that line the vasculature of the human body. These cells not only have specialized functions in the maintenance of homeostasis within the circulation and various tissues but they also have a major role in immune function. EC also represent an important replicative niche for a subset of viral, bacterial, and parasitic organisms that are present in the blood or lymph; however, there are major gaps in our knowledge regarding how pathogens interact with EC and how this influences disease outcome. In this article, we review the literature on EC-pathogen interactions and their role in innate and adaptive mechanisms of resistance to infection and highlight opportunities to address prominent knowledge gaps.
摘要
人体内有超过 10 万亿个内皮细胞（EC）排列在脉管系统中。这些细胞不仅在循环和各种组织中的内稳态维持方面具有特殊功能，而且在免疫功能方面也起着重要作用。EC 还代表了存在于血液或淋巴中的一部分病毒、细菌和寄生虫生物体的重要复制生态位；然而，我们对于病原体如何与 EC 相互作用以及这如何影响疾病结果的知识还存在很大的空白。在本文中，我们回顾了关于 EC-病原体相互作用及其在感染的先天和适应性抵抗机制中的作用的文献，并强调了解决突出知识空白的机会。
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