• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

人类c-rel序列的遗传特征分析。

Genetic characterization of human c-rel sequences.

作者信息

Brownell E, O'Brien S J, Nash W G, Rice N

出版信息

Mol Cell Biol. 1985 Oct;5(10):2826-31. doi: 10.1128/mcb.5.10.2826-2831.1985.

DOI:10.1128/mcb.5.10.2826-2831.1985
PMID:3016517
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC367021/
Abstract

We isolated and sequenced a human genomic-DNA segment that is homologous to a portion of v-rel, the transforming gene of reticuloendotheliosis virus (strain T). We also localized the human rel sequences to human chromosome 2 by screening a panel of rodent X human somatic-cell hybrids with the newly described human rel segment.

摘要

我们分离并测序了一段人类基因组DNA片段，该片段与网状内皮增生症病毒（T株）的转化基因v-rel的一部分同源。我们还通过用新描述的人类rel片段筛选一组啮齿动物X人类体细胞杂种，将人类rel序列定位到人类2号染色体上。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e39/367021/c30f2d0aa868/molcellb00106-0343-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e39/367021/e3b0eca889c1/molcellb00106-0341-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e39/367021/81a8b0a74932/molcellb00106-0343-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e39/367021/c30f2d0aa868/molcellb00106-0343-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e39/367021/e3b0eca889c1/molcellb00106-0341-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e39/367021/81a8b0a74932/molcellb00106-0343-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e39/367021/c30f2d0aa868/molcellb00106-0343-b.jpg

相似文献

1
Genetic characterization of human c-rel sequences.人类c-rel序列的遗传特征分析。
Mol Cell Biol. 1985 Oct;5(10):2826-31. doi: 10.1128/mcb.5.10.2826-2831.1985.
2
Structure and dimorphism of c-rel (turkey), the cellular homolog to the oncogene of reticuloendotheliosis virus strain T.c-rel（火鸡）的结构与二态性，它是网状内皮组织增生症病毒T株致癌基因的细胞同源物。
J Virol. 1984 Feb;49(2):521-9. doi: 10.1128/JVI.49.2.521-529.1984.
3
The Rel family: models for transcriptional regulation and oncogenic transformation.Rel家族：转录调控与致癌转化模型
Biochim Biophys Acta. 1992 Sep 14;1114(1):1-17. doi: 10.1016/0304-419x(92)90002-g.
4
Regional localization of the human c-rel locus using translocation chromosome analysis.利用易位染色体分析对人类c-rel基因座进行区域定位。
Oncogene. 1988 May;2(5):527-9.
5
Characterization of reticuloendotheliosis virus strain T DNA and isolation of a novel variant of reticuloendotheliosis virus strain T by molecular cloning.禽网状内皮组织增殖病病毒T株DNA的特性分析及通过分子克隆分离出禽网状内皮组织增殖病病毒T株的一种新型变体
J Virol. 1981 Dec;40(3):800-11. doi: 10.1128/JVI.40.3.800-811.1981.
6
Expression of the oncogene of avian reticuloendotheliosis virus in Escherichia coli and identification of the transforming protein in reticuloendotheliosis virus T-transformed cells.禽网状内皮组织增殖病病毒癌基因在大肠杆菌中的表达及网状内皮组织增殖病病毒T转化细胞中转化蛋白的鉴定
Proc Natl Acad Sci U S A. 1986 Feb;83(3):812-6. doi: 10.1073/pnas.83.3.812.
7
Oncogene expression in reticuloendotheliosis virus-transformed lymphoid cell lines and avian tissues.致癌基因在网状内皮组织增殖症病毒转化的淋巴样细胞系和禽类组织中的表达。
J Virol. 1986 Jan;57(1):371-5. doi: 10.1128/JVI.57.1.371-375.1986.
8
Activation of oncogenicity of the c-rel proto-oncogene.c-rel原癌基因致癌性的激活。
Mol Cell Biol. 1986 Dec;6(12):4709-16. doi: 10.1128/mcb.6.12.4709-4716.1986.
9
Structure and expression of c-rel, the cellular homolog to the oncogene of reticuloendotheliosis virus strain T.与网状内皮增生症病毒T株癌基因同源的细胞基因c-rel的结构与表达
J Virol. 1983 Jan;45(1):104-13. doi: 10.1128/JVI.45.1.104-113.1983.
10
The N-terminal env-derived amino acids of v-rel are required for full transforming activity.v-rel的N末端env衍生氨基酸对于完全转化活性是必需的。
Virology. 1990 Jul;177(1):106-15. doi: 10.1016/0042-6822(90)90464-3.

引用本文的文献

1
c-Rel is a Novel Oncogene in Lung Squamous Cell Carcinoma Regulating Cell Proliferation and Migration.c-Rel是肺鳞状细胞癌中一种调节细胞增殖和迁移的新型癌基因。
J Cancer. 2024 Mar 4;15(8):2329-2339. doi: 10.7150/jca.93766. eCollection 2024.
2
c-Rel Is the Pivotal NF-κB Subunit in Germinal Center Diffuse Large B-Cell Lymphoma: A LYSA Study.c-Rel是生发中心弥漫性大B细胞淋巴瘤中的关键核因子κB亚基：一项LYSA研究
Front Oncol. 2021 Apr 20;11:638897. doi: 10.3389/fonc.2021.638897. eCollection 2021.
3
The Unsolved Puzzle of c-Rel in B Cell Lymphoma.

本文引用的文献

1
A catalogue of splice junction sequences.剪接连接序列目录。
Nucleic Acids Res. 1982 Jan 22;10(2):459-72. doi: 10.1093/nar/10.2.459.
2
Mapping of an endogenous retroviral sequence to human chromosome 18.一个内源性逆转录病毒序列在人类18号染色体上的定位。
Nature. 1983;303(5912):74-7. doi: 10.1038/303074a0.
3
Dispersion of the ras family of transforming genes to four different chromosomes in man.人转化基因ras家族在四条不同染色体上的分散情况。
B细胞淋巴瘤中c-Rel未解决的谜题。
Cancers (Basel). 2019 Jul 4;11(7):941. doi: 10.3390/cancers11070941.
4
Curcuma Contra Cancer? Curcumin and Hodgkin's Lymphoma.姜黄能抗癌？姜黄素与霍奇金淋巴瘤
Cancer Growth Metastasis. 2013 Aug 8;6:35-52. doi: 10.4137/CGM.S11113. eCollection 2013.
5
The transcription factor NF-kappaB in the demosponge Amphimedon queenslandica: insights on the evolutionary origin of the Rel homology domain.在海绵动物昆士兰扁海绵中发现的转录因子NF-κB：对Rel同源结构域进化起源的见解
Dev Genes Evol. 2008 Jan;218(1):23-32. doi: 10.1007/s00427-007-0197-5. Epub 2008 Jan 4.
6
Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-kappa B.白细胞介素-8基因调控的独特机制涉及C/EBP和核因子κB之间的协同作用。
Mol Cell Biol. 1993 Nov;13(11):7191-8. doi: 10.1128/mcb.13.11.7191-7198.1993.
7
Chromosome 8 breakpoint far 3' of the c-myc oncogene in a Burkitt's lymphoma 2;8 variant translocation is equivalent to the murine pvt-1 locus.在伯基特淋巴瘤2;8变异易位中，8号染色体断点位于c-myc癌基因3'端远处，等同于小鼠的pvt-1基因座。
EMBO J. 1986 Nov;5(11):2845-51. doi: 10.1002/j.1460-2075.1986.tb04578.x.
8
Transcriptional induction of the murine c-rel gene with serum and phorbol-12-myristate-13-acetate in fibroblasts.血清和佛波醇-12-肉豆蔻酸酯-13-乙酸酯在成纤维细胞中对小鼠c-rel基因的转录诱导
Mol Cell Biol. 1989 Nov;9(11):5239-43. doi: 10.1128/mcb.9.11.5239-5243.1989.
9
A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human.小鼠11号染色体的综合遗传图谱揭示了小鼠和人类之间广泛的连锁保守性。
Genetics. 1989 May;122(1):153-61. doi: 10.1093/genetics/122.1.153.
10
Detection of c-rel-related transcripts in mouse hematopoietic tissues, fractionated lymphocyte populations, and cell lines.在小鼠造血组织、分离的淋巴细胞群体及细胞系中检测c-rel相关转录本。
Mol Cell Biol. 1987 Mar;7(3):1304-9. doi: 10.1128/mcb.7.3.1304-1309.1987.
Nature. 1983 Apr 28;302(5911):839-42. doi: 10.1038/302839a0.
4
Isolation of amplified DNA sequences from IMR-32 human neuroblastoma cells: facilitation by fluorescence-activated flow sorting of metaphase chromosomes.从IMR-32人神经母细胞瘤细胞中分离扩增的DNA序列：通过中期染色体的荧光激活流式分选进行辅助
Proc Natl Acad Sci U S A. 1983 Jul;80(13):4069-73. doi: 10.1073/pnas.80.13.4069.
5
Translocation of an immunoglobulin kappa locus to a region 3' of an unrearranged c-myc oncogene enhances c-myc transcription.免疫球蛋白κ基因座易位至未重排的c-myc癌基因3'端区域可增强c-myc转录。
Proc Natl Acad Sci U S A. 1983 Dec;80(24):7581-5. doi: 10.1073/pnas.80.24.7581.
6
Specific chromosomal translocations and the genesis of B-cell-derived tumors in mice and men.小鼠和人类中特定染色体易位与B细胞源性肿瘤的发生
Cell. 1983 Feb;32(2):311-5. doi: 10.1016/0092-8674(83)90449-x.
7
A novel alteration in the structure of an activated c-myc gene in a variant t(2;8) Burkitt lymphoma.一种变异型t(2;8)伯基特淋巴瘤中活化c-myc基因结构的新型改变。
Cell. 1984 Jun;37(2):511-20. doi: 10.1016/0092-8674(84)90381-7.
8
Structure and dimorphism of c-rel (turkey), the cellular homolog to the oncogene of reticuloendotheliosis virus strain T.c-rel（火鸡）的结构与二态性，它是网状内皮组织增生症病毒T株致癌基因的细胞同源物。
J Virol. 1984 Feb;49(2):521-9. doi: 10.1128/JVI.49.2.521-529.1984.
9
Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations.用亚硝基甲基脲诱导大鼠发生乳腺癌涉及通过单点突变对H-ras-1基因座的恶性激活。
Nature. 1983;306(5944):658-61. doi: 10.1038/306658a0.
10
Nucleotide sequence of v-rel: the oncogene of reticuloendotheliosis virus.v-rel的核苷酸序列：网状内皮增生症病毒的癌基因。
Proc Natl Acad Sci U S A. 1983 Oct;80(20):6229-33. doi: 10.1073/pnas.80.20.6229.