Shimizu Yukiko, Yoshitani Kazuyasu, Murotani Kenta, Kujira Kazuto, Kurozumi Yuma, Fukuhara Rei, Taniguchi Ryoji, Toma Masanao, Miyamoto Tadashi, Kita Yoshio, Takatsu Yoshiki, Sato Yukihito
Department of Cardiology Hyogo Prefectural Amagasaki General Medical Center Amagasaki Japan.
Center for Clinical Research Aichi Medical University Nagakute Japan.
J Arrhythm. 2018 Jun 4;34(4):410-417. doi: 10.1002/joa3.12075. eCollection 2018 Aug.
The aim of this study was to explore whether the pouch depth influenced the radiofrequency (RF) duration and total delivered RF energy for cavotricuspid isthmus (CTI) ablation and define the cutoff value for a deep pouch-specified ablation strategy.
This study included 94 atrial fibrillation (AF) patients (56 males, age 68 ± 8.0 years). With intracardiac echocardiography, the isthmus length and pouch depth were precisely measured. After a standard AF ablation, all patients underwent the CTI ablation along the lateral isthmus. If bidirectional block could not be achieved, the ablation catheter was deflected more than 90 degrees to ablate inside the pouch (knuckle-curve ablation).
Seventy-two patients (76.6%) had a sub-Eustachian pouch. Bidirectional block could be achieved in all patients. By a univariate logistic regression analysis, only the pouch depth was significantly correlated with the RF duration ( = .005) and RF energy ( = .006). A multivariate logistic regression analysis also revealed the pouch depth was the sole factor that influenced the RF duration ( = .001) and RF energy ( = .001). Among the 72 patients, 21 patients needed a knuckle-curve ablation. Using a receiver operating characteristic curve, the optimal cutoff value of the pouch depth for a knuckle-curve ablation was 3.7 mm with a sensitivity of 90% and specificity of 69%.
The sub-Eustachian pouch depth was the sole factor that influenced the RF duration and energy in the CTI ablation. If the pouch was deeper than 3.7 mm, a deep pouch-specified ablation strategy would be needed.
本研究旨在探讨心包窦深度是否会影响三尖瓣峡部(CTI)消融的射频(RF)持续时间和总传递射频能量,并确定针对深心包窦的消融策略的临界值。
本研究纳入了94例心房颤动(AF)患者(56例男性,年龄68±8.0岁)。通过心内超声心动图精确测量峡部长度和心包窦深度。在进行标准的AF消融后,所有患者均沿外侧峡部进行CTI消融。如果无法实现双向阻滞,则将消融导管偏转超过90度在心包窦内进行消融(指关节曲线消融)。
72例患者(76.6%)有下腔静脉窦心包窦。所有患者均能实现双向阻滞。通过单因素逻辑回归分析,仅心包窦深度与RF持续时间(P = 0.005)和RF能量(P = 0.006)显著相关。多因素逻辑回归分析还显示,心包窦深度是影响RF持续时间(P = 0.001)和RF能量(P = 0.001)的唯一因素。在这72例患者中,21例患者需要进行指关节曲线消融。使用受试者工作特征曲线,指关节曲线消融的心包窦深度最佳临界值为3.7 mm,敏感性为90%,特异性为69%。
下腔静脉窦心包窦深度是影响CTI消融中RF持续时间和能量的唯一因素。如果心包窦深度超过3.7 mm,则需要采用针对深心包窦的消融策略。