van Doorn Tess, Groenendijk Ilse M, Scheepe Jeroen R, Blok Bertil F M
Department of Urology, Erasmus Medical Center, Rotterdam, the Netherlands (TvD, IMG, JRS, BFMB).
Int J MS Care. 2022 Mar-Apr;24(2):67-73. doi: 10.7224/1537-2073.2020-105. Epub 2021 Jun 10.
Neurogenic bowel dysfunction (NBD), like fecal incontinence and constipation, is a common symptom of disease in patients with multiple sclerosis (MS). The NBD score is a validated symptom-based questionnaire consisting of 10 multiple-choice questions. The aim of this study was to validate the Dutch version of the NBD score in patients with MS, creating an objective measuring tool of bowel dysfunction.
Translation and validation of the NBD score was performed according to standardized guidelines. Adult patients with MS visiting a urology department completed a set of questionnaires (test): the NBD score, the Fecal Incontinence Quality of Life scale (FIQL), the Fecal Incontinence Severity Index (FISI), and the EQ-5D 3-Level questionnaire (EQ-5D-3L). After 1 to 2 weeks, the questionnaires were completed again (retest). A control group recruited at a general practitioner's practice completed the questionnaires once. Data were analyzed for measurement properties.
Sixty-one patients and 50 controls were included. Content validity was adequate, internal consistency was moderate (Cronbach α = 0.57 and 0.41), and reproducibility was excellent (interclass correlation coefficient = 0.78). Criterion validity was confirmed; the NBD score correlated moderately/strongly with the FIQL, FISI, and EQ-5D-3L. The NBD scores in the patient group were significantly higher than those in the control group, demonstrating good construct validity.
The Dutch version of the NBD score showed moderate to good validity and good reliability for assessment of NBD in patients with MS.
神经源性肠道功能障碍（NBD）与大便失禁和便秘一样，是多发性硬化症（MS）患者常见的疾病症状。NBD评分是一种经过验证的基于症状的问卷，由10个多项选择题组成。本研究的目的是验证MS患者中NBD评分的荷兰语版本，创建一种肠道功能障碍的客观测量工具。
根据标准化指南对NBD评分进行翻译和验证。就诊于泌尿外科的成年MS患者完成了一组问卷（测试）：NBD评分、大便失禁生活质量量表（FIQL）、大便失禁严重程度指数（FISI）和EQ-5D 3级问卷（EQ-5D-3L）。1至2周后，再次完成问卷（复测）。在全科医生诊所招募的对照组患者完成一次问卷。对数据进行测量属性分析。
纳入61例患者和50例对照。内容效度充分，内部一致性中等（Cronbach α分别为0.57和0.41），再现性良好（组内相关系数=0.78）。标准效度得到证实；NBD评分与FIQL、FISI和EQ-5D-3L呈中度/高度相关。患者组的NBD评分显著高于对照组，显示出良好的结构效度。
NBD评分的荷兰语版本在评估MS患者的NBD方面显示出中等至良好的效度和良好的信度。
