Fojo A, Lebo R, Shimizu N, Chin J E, Roninson I B, Merlino G T, Gottesman M M, Pastan I
Somat Cell Mol Genet. 1986 Jul;12(4):415-20. doi: 10.1007/BF01570737.
Multidrug resistance in several human cell lines correlates with amplification or increased expression of two related DNA sequences, designated mdr1 and mdr2. These DNA sequences were used as probes for hybridization with DNA with a panel of human-mouse somatic cell hybrids and from individual human chromosomes separated by fluorescence-activated chromosome sorting. By these assays, both mdr1 and mdr2 sequences were localized to chromosome 7.
几种人类细胞系中的多药耐药性与两个相关DNA序列（命名为mdr1和mdr2）的扩增或表达增加相关。这些DNA序列被用作探针，与一组人-鼠体细胞杂种的DNA以及通过荧光激活染色体分选分离出的单个人类染色体的DNA进行杂交。通过这些检测，mdr1和mdr2序列都定位于7号染色体。
