非甾体抗炎药对人及大鼠外周血白细胞体外迁移的作用
Action of nonsteroidal, anti-inflammatory drugs on human and rat peripheral leucocyte migration in vitro.
作者信息
Brown K A, Collins A J
出版信息
Ann Rheum Dis. 1977 Jun;36(3):239-43. doi: 10.1136/ard.36.3.239.
Abstract
Using an in vitro system of cell migration from glass capillary tubes, the nonsteroidal, anti-inflammatory agents sodium salicylate, aspirin, ibuprofen, phenylbutazone, and indomethacin were shown to inhibit the migration of human peripheral leucocytes in a dose-related manner. This drug action was not confined to one species, as shown by the modification of rat peripheral leucocyte motility by sodium salicylate and aspirin. The relevance of the human findings to the clinical effectiveness of these agents is discussed.
摘要
利用玻璃毛细管中细胞迁移的体外系统，已表明非甾体抗炎药水杨酸钠、阿司匹林、布洛芬、保泰松和吲哚美辛以剂量相关的方式抑制人外周血白细胞的迁移。水杨酸钠和阿司匹林对大鼠外周血白细胞运动性的改变表明，这种药物作用并不局限于某一物种。文中讨论了这些人体研究结果与这些药物临床疗效的相关性。
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