通过开环复分解聚合诱导自组装制备酶响应性聚合物纳米粒子。
Enzyme-Responsive Polymer Nanoparticles via Ring-Opening Metathesis Polymerization-Induced Self-Assembly.
机构信息
Department of Chemistry, Department of Materials Science and Engineering, Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois, 60208-3113, USA.
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California, 92093, USA.
出版信息
Macromol Rapid Commun. 2019 Jan;40(2):e1800467. doi: 10.1002/marc.201800467. Epub 2018 Sep 3.
Open-to-air aqueous-phase ring-opening metathesis polymerization-induced self-assembly (ROMPISA) is reported for forming well-defined peptide polymer nanoparticles at room temperature and with high solids concentrations (10 w/w%). For these materials, ROMPISA is shown to provide control over molecular weight with high conversion while open-to-air. Moreover, these peptide polymer nanoparticles can spontaneously rearrange into larger aggregate scaffolds in the presence of the proteolytic enzyme, thermolysin. This work demonstrates the robust nature of ROMPISA, highlighted here for the preparation of stimuli-responsive nanostructures in one pot, in air.
开环易位聚合诱导自组装（ROMPISA）在室温下以高固含量（10 w/w%）形成具有明确结构的肽聚合物纳米粒子。对于这些材料，ROMPISA 提供了在开放空气条件下高转化率的分子量控制。此外，这些肽聚合物纳米粒子在存在蛋白水解酶，胰凝乳蛋白酶的情况下可以自发重新排列成较大的聚集支架。这项工作证明了 ROMPISA 的强大性质，在这里突出了在空气中一锅法制备刺激响应性纳米结构。
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