Department of Cell and Developmental Biology, Biocentre, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Department of Cell and Developmental Biology, Biocentre, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Trends Parasitol. 2018 Dec;34(12):1056-1067. doi: 10.1016/j.pt.2018.08.002. Epub 2018 Sep 1.
While the African trypanosomes are among the best-studied parasites, almost everything we know about them is based on the brucei group, which includes the human-infective sleeping sickness parasites and the causative agent of the cattle plague nagana. The past decades have seen an ever-more detailed molecular dissection of Trypanosoma brucei, which today is an accepted cell biological model system. Therefore, recent work on some fundamental aspects of trypanosome biology surprises, as we realise that our knowledge about parasite motility and tropism in the changing host microenvironments is far from definitive. In this review, we highlight a few examples of neglected parasitological questions, which may open (or reopen) a new chapter of trypanosome research.
虽然非洲锥虫是研究得最好的寄生虫之一，但我们几乎所有的认识都基于布鲁斯氏锥虫群，它包括感染人类的昏睡病寄生虫和引起牛瘟的病原体。在过去的几十年里，对布氏锥虫进行了越来越详细的分子剖析，如今它已成为公认的细胞生物学模型系统。因此，最近关于锥虫生物学一些基本方面的研究令人惊讶，因为我们意识到，我们对于寄生虫在宿主微环境变化中的运动和趋向性的了解还远未确定。在这篇综述中，我们强调了一些被忽视的寄生虫学问题的例子，这些问题可能会开启（或重新开启）锥虫研究的新篇章。
