State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, Department of Biochemistry, Nanjing University, Nanjing 210093, P. R. China.
Chem Commun (Camb). 2018 Oct 9;54(81):11391-11394. doi: 10.1039/c8cc05690k.
By employing DNA nanoflower blooming in the nanochannels of porous anodic alumina (PAA), a nanochannel platform for microRNA (miRNA) detection has been proposed. Significant steric and electrostatic hindrance of the miRNA-initiated DNA-nanoflower growth may also amplify the signal readout for miRNA detection to give excellent sensitivity, selectivity and reproducibility.
通过在多孔阳极氧化铝 (PAA) 的纳米通道中实现 DNA 纳米花的绽放，提出了一种用于 microRNA (miRNA) 检测的纳米通道平台。miRNA 引发的 DNA 纳米花生长的显著空间和静电阻碍也可能放大 miRNA 检测的信号读取，从而提供出色的灵敏度、选择性和重现性。
