John Wayne Cancer Institute at Providence Saint John's Health Center, 2200 Santa Monica Blvd, Suite 131, Santa Monica, CA, 90404, USA.
Clin Exp Metastasis. 2018 Aug;35(5-6):471-485. doi: 10.1007/s10585-018-9936-4. Epub 2018 Sep 5.
Sentinel lymph node (SLN) based pelvic lymph node dissection (PLND) in prostate cancer (PCa) is appealing over the time, cost and morbidity classically attributed to conventional PLND during radical prostatectomy. The initial report of feasibility of the SLN concept in prostate cancer was nearly 20 years ago. However, PLND based on the SLN concept, either SLN biopsy of a single node or targeted SLN dissection of multiple nodes, is still considered investigational in PCa. To better appreciate the challenges, and potential solutions, associated with SLN-based PLND in PCa, this review will discuss the rationale behind PLND in PCa and evaluate current SLN efforts in the most commonly diagnosed malignancy in men in the US.
前哨淋巴结（SLN）在基于前列腺癌（PCa）的盆腔淋巴结清扫术（PLND）中，相较于传统根治性前列腺切除术相关的时间、费用和发病率优势明显。最初关于 SLN 概念在前列腺癌中可行性的报告是在将近 20 年前。然而，基于 SLN 概念的 PLND，无论是单个节点的 SLN 活检还是多个节点的靶向 SLN 切除术，在 PCa 中仍被认为是探索性的。为了更好地了解 SLN 基础上的 PLND 在 PCa 中面临的挑战和潜在解决方案，本综述将讨论 PLND 在 PCa 中的基本原理，并评估目前在美国男性最常见的恶性肿瘤中 SLN 的努力。
