Department of Endocrinology, Drum Tower Clinical College of Nanjing Medical University, Nanjing, China.
Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China.
Diabetes Metab. 2019 Sep;45(4):341-346. doi: 10.1016/j.diabet.2018.08.005. Epub 2018 Sep 3.
Type 1 innate lymphoid cells (ILC1s) play a major role in regulating systemic inflammatory diseases. However, the relationship between ILC1s and type 2 diabetes (T2D) remains unclear. Thus, the present study investigated the relationship between ILC1s and glucose homoeostasis in humans.
A total of 37 newly diagnosed T2D patients and 32 subjects with normal glucose tolerance (NGT), matched for age and body mass index (BMI), were enrolled in the study. Flow cytometric analysis of ILC1s derived from peripheral blood mononuclear cells (PBMCs) and omental adipose tissue was performed.
T2D patients displayed greater numbers and frequencies of circulating and adipose tissue ILC1s (P < 0.05) compared with NGT subjects, and the two types of ILC1s correlated positively with each other. Circulating ILC1s were positively associated with glycated haemoglobin (HbA), fasting plasma glucose (FPG), homoeostasis model assessment for insulin resistance (HOMA-IR), adipose tissue insulin resistance index (Adipo-IR) and serum free fatty acids (FFAs). A logistic regression model revealed that patients with higher ILC1 levels exhibited a 13.481-fold greater risk of developing T2D.
This study is the first to provide evidence that ILC1 abnormalities are involved in the development of diabetes. The data also suggest a potential role of ILC1s as therapeutic indicators in the treatment of T2D.
1 型固有淋巴细胞（ILC1）在调节系统性炎症性疾病方面发挥着重要作用。然而，ILC1 与 2 型糖尿病（T2D）之间的关系尚不清楚。因此，本研究探讨了 ILC1 与人类葡萄糖稳态之间的关系。
共纳入 37 例新诊断的 T2D 患者和 32 例血糖正常的受试者（NGT），按年龄和体重指数（BMI）匹配。对来源于外周血单个核细胞（PBMC）和网膜脂肪组织的 ILC1 进行流式细胞术分析。
与 NGT 受试者相比，T2D 患者的循环和脂肪组织 ILC1 数量和频率更高（P<0.05），且两种类型的 ILC1 相互之间呈正相关。循环 ILC1 与糖化血红蛋白（HbA）、空腹血浆葡萄糖（FPG）、胰岛素抵抗评估的稳态模型（HOMA-IR）、脂肪组织胰岛素抵抗指数（Adipo-IR）和血清游离脂肪酸（FFAs）呈正相关。逻辑回归模型显示，ILC1 水平较高的患者发生 T2D 的风险增加了 13.481 倍。
本研究首次提供了证据表明 ILC1 异常参与了糖尿病的发生。数据还表明，ILC1 可能作为治疗 T2D 的治疗指标。
