Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
Cyber-Physical Systems, Technische Universität Wien, Vienna, Austria.
Philos Trans R Soc Lond B Biol Sci. 2018 Sep 10;373(1758):20170379. doi: 10.1098/rstb.2017.0379.
The OpenWorm project has the ambitious goal of producing a highly detailed model of the nematode A crucial part of this work will be a model of the nervous system encompassing all known cell types and connections. The appropriate level of biophysical detail required in the neuronal model to reproduce observed high-level behaviours in the worm has yet to be determined. For this reason, we have developed a framework, c302, that allows different instances of neuronal networks to be generated incorporating varying levels of anatomical and physiological detail, which can be investigated and refined independently or linked to other tools developed in the OpenWorm modelling toolchain.This article is part of a discussion meeting issue 'Connectome to behaviour: modelling at cellular resolution'.
OpenWorm 项目有一个雄心勃勃的目标，即制作一个高度详细的线虫模型。这项工作的一个关键部分将是一个神经系统模型，涵盖所有已知的细胞类型和连接。为了在神经元模型中重现线虫的观察到的高级行为，需要确定适当的生物物理细节水平。出于这个原因，我们开发了一个框架 c302，它允许生成不同实例的神经元网络，这些网络包含不同程度的解剖学和生理学细节，可以独立进行研究和改进，或者与 OpenWorm 建模工具链中开发的其他工具链接。本文是“从连接组到行为：在细胞分辨率下进行建模”讨论专题的一部分。
