Shenzhen Key Laboratory of Edible and Medicinal Bioresources, Shenzhen Research Institute, Hi-Tech Park, Shenzhen, 518000, China.
Food Funct. 2018 Oct 17;9(10):5139-5149. doi: 10.1039/c8fo00991k.
Edible bird's nest (EBN), an Asian health food, contains insoluble proteins and conjugated N-acetylneuraminic acid (NANA) that are difficult to be absorbed by humans. In order to increase the nutritional value of EBN, we developed methods to digest EBN targeting the release of proteins and NANA. By using simulated gastric fluid under acidic conditions, the complex proteins were fully digested into smaller peptides, and in parallel, NANA was fully released from the conjugated form. The completely digested EBN showed better nutraceutical properties. In a skin whitening test, the EBN digest showed stronger inhibition of melanogenesis of cultured B16 cells and enzymatic activity of tyrosinase, as compared to that of undigested EBN. In addition, the EBN digest exhibited stronger osteogenic activity in cultured osteoblasts. Thus, the complete digestion of EBN could be applied to the development of a new generation of EBN health food products, including EBN drinks and skincare products.
食用燕窝（EBN）是一种亚洲保健食品，含有不易被人体吸收的不溶性蛋白质和结合型 N-乙酰神经氨酸（NANA）。为了提高 EBN 的营养价值，我们开发了针对蛋白质和 NANA 释放的 EBN 消化方法。通过在酸性条件下使用模拟胃液，将复杂的蛋白质完全消化成较小的肽，同时将 NANA 从结合形式中完全释放出来。完全消化的 EBN 显示出更好的营养保健品特性。在美白测试中，与未消化的 EBN 相比，EBN 消化物对培养的 B16 细胞黑色素生成和酪氨酸酶活性具有更强的抑制作用。此外，EBN 消化物在培养的成骨细胞中表现出更强的成骨活性。因此，EBN 的完全消化可应用于新一代 EBN 保健食品的开发，包括 EBN 饮料和护肤品。
