Department of Reconstructive Surgery and Hand Surgery, AOU "Ospedali Riuniti,", Ancona, Italy.
J Cell Physiol. 2019 Apr;234(4):3362-3375. doi: 10.1002/jcp.27299. Epub 2018 Sep 12.
Peripheral nerve physiology and regeneration has been observed and investigated in literature but surgical applications to reconstruct and restore motor or sensory functions are still in a developmental phase. The peripheral nerve progresses slowly and incompletely compared with other tissues, it may provoke separations of the nerve stumps and the axonal proliferation of the conduits is restricted to 30 mm. Recent surgical attempts to treat proximal nerve injures include direct nerve restoration, transfer, and autografting measures with favorable results. Moreover, studies are suggesting that engineering tissue tubes maybe as effective as nerve grafting to restore separations of more than 4 cm toward optimal nerve repair.
周围神经生理学和再生在文献中已经得到了观察和研究，但用于重建和恢复运动或感觉功能的外科应用仍处于发展阶段。与其他组织相比，周围神经的进展缓慢且不完全，它可能会导致神经残端分离，并且导管中的轴突增殖仅限于 30mm。最近，为了治疗近端神经损伤，外科医生尝试了直接神经修复、转移和自体移植物等措施，取得了良好的效果。此外，研究表明，工程组织管可能与神经移植一样有效，可以修复超过 4cm 的分离，从而实现最佳的神经修复。
