Wei Hu, Jing Hu, Wei Qian, Wei Guo, Heng Zhou
Department of Radiology, the Fifth Hospital of Wuhan Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China.
Medicine (Baltimore). 2018 Sep;97(37):e12282. doi: 10.1097/MD.0000000000012282.
The associations of the risk of lung cancer with the vitamin D intake and serum level are controversial. We performed a comprehensive dose-response meta-analysis to evaluate the precise relationships between the above mentioned parameters.We performed a web search of the PubMed, Medline, and Embase databases to identify potential studies that evaluated the relationships between vitamin D intake or serum 25-hydroxyvitamin D (25([OH]D) levels and the risk of lung cancer on December 5, 2017. According to the inclusion and exclusive criteria, 16 studies were included in this meta-analysis. The pooled relative risks (RRs) with 95% confidence intervals (CIs) were used to assess the strength of the associations. A dose-response analysis was conducted to quantitate the relationship between the serum 25(OH)D or vitamin D intake and the risk of lung cancer.The pooled RR (highest level vs lowest level) showed that the serum 25(OH)D level was not associated with the risk of lung cancer (RR = 1.046, 95% CI = 0.945-1.159). A high vitamin D intake was inversely correlated with the lung cancer risk (RR = 0.854, 95% CI = 0.741-0.984). No significant dose-response relationship was observed between the serum 25(OH)D level and the lung cancer risk. The linearity model of the dose-response analysis indicated that with every 100 IU/day increase in vitamin D intake, the risk of lung cancer decreased by 2.4% (RR = 0.976, 95% CI = 0.957-0.995, P = .018).A high vitamin D intake provides limited protection against lung cancer carcinogenesis.
肺癌风险与维生素D摄入量及血清水平之间的关联存在争议。我们进行了一项全面的剂量反应荟萃分析，以评估上述参数之间的精确关系。2017年12月5日，我们在PubMed、Medline和Embase数据库中进行了网络搜索，以确定评估维生素D摄入量或血清25-羟基维生素D（25[OH]D）水平与肺癌风险之间关系的潜在研究。根据纳入和排除标准，本荟萃分析纳入了16项研究。采用合并相对风险（RRs）及95%置信区间（CIs）来评估关联强度。进行剂量反应分析以量化血清25(OH)D或维生素D摄入量与肺癌风险之间的关系。合并RR（最高水平与最低水平相比）显示，血清25(OH)D水平与肺癌风险无关（RR = 1.046，95% CI = 0.945 - 1.159）。高维生素D摄入量与肺癌风险呈负相关（RR = 0.854，95% CI = 0.741 - 0.984）。未观察到血清25(OH)D水平与肺癌风险之间存在显著的剂量反应关系。剂量反应分析的线性模型表明，维生素D摄入量每增加100 IU/天，肺癌风险降低2.4%（RR = 0.976，95% CI = 0.957 - 0.995，P = 0.018）。高维生素D摄入量对肺癌致癌作用的保护作用有限。
