血浆25-羟基维生素D水平、维生素D摄入量与胰腺癌风险或死亡率：一项荟萃分析。
Plasma 25-hydroxyvitamin D levels, vitamin D intake, and pancreatic cancer risk or mortality: a meta-analysis.
作者信息
Zhang Xi, Huang Xuan-Zhang, Chen Wen-Jun, Wu Jian, Chen You, Wu Cong-Cong, Wang Zhen-Ning
机构信息
Department of Chemotherapy and Radiotherapy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Lucheng, Wenzhou 325027, P.R. China.
Department of Pediatric Dentistry, The Wenzhou Dental Hospital, Lucheng, Wenzhou 325027, P.R. China.
出版信息
Oncotarget. 2017 Jun 29;8(38):64395-64406. doi: 10.18632/oncotarget.18888. eCollection 2017 Sep 8.
BACKGROUND
The associations between vitamin D status, including plasma 25-hydroxyvitamin D [25(OH)D] levels and vitamin D intake, and pancreatic cancer risk and mortality are inconsistent. The aims of this study are to evaluate the antitumor and therapeutic effects of vitamin D status for pancreatic cancer patients.
METHODS
A literature search for relevant studies was conducted using PubMed and Embase databases. Risk ratio (RR), hazard ratio (HR), and 95% confidence interval (CI) were used as the effect measures. All statistical analyses were performed using Stata software 12.0.
RESULTS
Our results indicated that high plasma 25(OH)D levels were inversely associated with pancreatic cancer mortality without significant heterogeneity (HR=0.81, 95% CI=0.68-0.96). However, high plasma 25(OH)D levels could not reduce pancreatic cancer risk (RR=1.02, 95% CI=0.66-1.57). Moreover, vitamin D intake was also not associated with pancreatic cancer risk (RR=1.11, 95% CI=0.67-1.86).
CONCLUSIONS
Our results indicate that high plasma 25(OH)D levels were significantly associated with improved survival in pancreatic cancer patients. However, there were no significant associations between vitamin D intake or plasma 25(OH)D levels and pancreatic cancer risk.
背景
维生素D状态，包括血浆25-羟基维生素D[25(OH)D]水平与维生素D摄入量，与胰腺癌风险及死亡率之间的关联并不一致。本研究旨在评估维生素D状态对胰腺癌患者的抗肿瘤及治疗效果。
方法
使用PubMed和Embase数据库对相关研究进行文献检索。风险比（RR）、风险比（HR）及95%置信区间（CI）用作效应量。所有统计分析均使用Stata软件12.0进行。
结果
我们的结果表明，血浆25(OH)D高水平与胰腺癌死亡率呈负相关，且无显著异质性（HR=0.81，95%CI=0.68-0.96）。然而，血浆25(OH)D高水平并不能降低胰腺癌风险（RR=1.02，95%CI=0.66-1.57）。此外，维生素D摄入量也与胰腺癌风险无关（RR=1.11，95%CI=0.67-1.86）。
结论
我们的结果表明，血浆25(OH)D高水平与胰腺癌患者生存率提高显著相关。然而，维生素D摄入量或血浆25(OH)D水平与胰腺癌风险之间并无显著关联。
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