人源环状RNA_0033155：一种潜在的非小细胞肺癌新型生物标志物。
Hsa_circ_0033155: A potential novel biomarker for non-small cell lung cancer.
作者信息
Gu Xiaohua, Wang Gang, Shen Hui, Fei Xiaoyun
机构信息
Department of Respiratory Medicine, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China.
State Key Laboratory of Bioreactor Engineering, School of Biotechnology, East China University of Science and Technology, Shanghai 200237, P.R. China.
出版信息
Exp Ther Med. 2018 Oct;16(4):3220-3226. doi: 10.3892/etm.2018.6565. Epub 2018 Aug 2.
Circular RNAs (circRNAs) are a novel type of endogenous RNAs and increasing evidence have uncovered the important role of circRNA in tumor progression; however, the function of circRNAs in non-small cell lung cancer (NSCLC) remains largely unclear. In the present study, it was demonstrated that the expression level of hsa_circ_0033155 was significantly downregulated in NSCLC tissue and the expression of hsa_circ_0033155 correlated with lymphatic metastasis. In order to further investigate the possible role of hsa_circ_0033155 in NSCLC progression, circRNA was overexpressed in NSCLC cells and it was observed that the overexpression of hsa_circ_0033155 significantly decreased cell proliferation, colony formation and migration, and elevated the level of phosphatase and tensin homolog deleted on chromosome 10, a tumor suppressor in many types of tumor. In conclusion, hsa_circ_0033155 may serve as a prospective biomarker for detection and a promising therapeutic target for NSCLC.
环状RNA（circRNAs）是一类新型的内源性RNA，越来越多的证据揭示了circRNA在肿瘤进展中的重要作用；然而，circRNAs在非小细胞肺癌（NSCLC）中的功能仍不清楚。在本研究中，已证明hsa_circ_0033155在NSCLC组织中的表达水平显著下调，且hsa_circ_0033155的表达与淋巴转移相关。为了进一步研究hsa_circ_0033155在NSCLC进展中可能的作用，在NSCLC细胞中过表达circRNA，观察到hsa_circ_0033155的过表达显著降低了细胞增殖、集落形成和迁移，并提高了10号染色体上缺失的磷酸酶和张力蛋白同源物的水平，该蛋白是多种肿瘤中的一种肿瘤抑制因子。总之，hsa_circ_0033155可能作为NSCLC检测的潜在生物标志物和有前景的治疗靶点。
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