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Molecular localization, developmental expression and nucleotide sequence of the alpha-methyldopa hypersensitive gene of Drosophila.果蝇α-甲基多巴超敏基因的分子定位、发育表达及核苷酸序列
Genetics. 1986 Oct;114(2):453-67. doi: 10.1093/genetics/114.2.453.
2
Evidence for evolutionary duplication of genes in the dopa decarboxylase region of Drosophila.果蝇多巴脱羧酶区域基因进化复制的证据。
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3
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4
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1
3,4-Dihydroxyphenylacetaldehyde synthase evolved an ordered structure to deliver oxygen to pyridoxal 5'-phosphate for cuticle assembly in the mosquito Aedes aegypti.3,4-二羟基苯乙醛合酶进化出一种有序结构，以便将氧气传递给5'-磷酸吡哆醛，用于埃及伊蚊的表皮组装。
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5
The alpha methyl dopa hypersensitive gene, 1(2)amd, and two adjacent genes in Drosophila melanogaster: physical location and direct effects of amd on catecholamine metabolism.果蝇中的α-甲基多巴超敏基因1(2)amd及两个相邻基因：物理定位和amd对儿茶酚胺代谢的直接影响
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6
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7
The non-dosage compensated LSP1-alpha gene of Drosophila melanogaster lies immediately downstream of the dosage compensated L12 gene.黑腹果蝇的非剂量补偿LSP1-α基因紧邻剂量补偿L12基因的下游。
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On the Components of Segregation Distortion in DROSOPHILA MELANOGASTER. II. Deletion Mapping and Dosage Analysis of the SD Locus.在黑腹果蝇的分离失真成分上。二。SD 基因座的缺失作图和剂量分析。
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Genetic activity along 315 kb of the Drosophila chromosome.果蝇染色体上 315kb 范围内的遗传活性。
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A simple method for displaying the hydropathic character of a protein.一种展示蛋白质亲水性特征的简单方法。
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Cuticle protein genes of Drosophila: structure, organization and evolution of four clustered genes.果蝇的表皮蛋白基因：四个成簇基因的结构、组织与进化
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The genetics of dopa decarboxylase in Drosophila melanogaster. IV. The genetics and cytology of the 37B10-37D1 region.黑腹果蝇中多巴脱羧酶的遗传学。IV. 37B10 - 37D1区域的遗传学与细胞学
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Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.真核生物mRNA翻译起始位点上游序列的汇编与分析。
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The 3' end of drosophila histone H3 mRNA is produced by a processing activity in vitro.果蝇组蛋白H3 mRNA的3'端是在体外通过一种加工活性产生的。
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Transcripts of the six Drosophila actin genes accumulate in a stage- and tissue-specific manner.六种果蝇肌动蛋白基因的转录本以阶段和组织特异性的方式积累。
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果蝇α-甲基多巴超敏基因的分子定位、发育表达及核苷酸序列

Molecular localization, developmental expression and nucleotide sequence of the alpha-methyldopa hypersensitive gene of Drosophila.

作者信息

Marsh J L, Erfle M P, Leeds C A

出版信息

Genetics. 1986 Oct;114(2):453-67. doi: 10.1093/genetics/114.2.453.

DOI:10.1093/genetics/114.2.453
PMID:3021571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1202950/
Abstract

The region surrounding the dopa decarboxylase gene of Drosophila contains a cluster of functionally related genes, many of which affect cuticle development and/or catecholamine metabolism. In this report we describe the molecular mapping and sequencing of a full-length cDNA copy of a transcript that maps to the alpha-methyldopa hypersensitive region. Developmental RNA blots show stage-specific patterns of transcription and multiple RNA transcripts. A 2-kb transcript is most abundant at about 12 hr of embryogenesis, and lower levels are detected throughout most of embryogenesis. Lower levels of this transcript are also detected in adults. Smaller stage-specific transcripts are detected in late third-instar larvae. This pattern of transcription is consistent with the known lethal phases and phenotypes of the alpha-methyldopa hypersensitive gene (amd). Based on map position, pattern of transcription, homology with dopa decarboxylase and association with altered DNA in mutants, we conclude that this transcript represents the amd gene.

摘要

果蝇多巴脱羧酶基因周围的区域包含一组功能相关的基因，其中许多基因影响表皮发育和/或儿茶酚胺代谢。在本报告中，我们描述了一个转录本的全长cDNA拷贝的分子定位和测序，该转录本定位于α-甲基多巴超敏区域。发育RNA印迹显示了转录的阶段特异性模式和多个RNA转录本。一个2kb的转录本在胚胎发育约12小时时最为丰富，在胚胎发育的大部分时间里检测到的水平较低。在成虫中也检测到该转录本的较低水平。在三龄晚期幼虫中检测到较小的阶段特异性转录本。这种转录模式与α-甲基多巴超敏基因（amd）已知的致死阶段和表型一致。基于图谱位置、转录模式、与多巴脱羧酶的同源性以及与突变体中DNA改变的关联，我们得出结论，该转录本代表amd基因。