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具有荧光硅壳层的等离子体和磁性纳米粒子的组装用于三功能 SERS-磁性-荧光探针及其生物应用。

Assembly of Plasmonic and Magnetic Nanoparticles with Fluorescent Silica Shell Layer for Tri-functional SERS-Magnetic-Fluorescence Probes and Its Bioapplications.

机构信息

Department of Bioscience and Biotechnology, Konkuk University, Seoul, 05029, Republic of Korea.

School of Chemical and Biological Engineering, Seoul National University, Seoul, 08826, Republic of Korea.

出版信息

Sci Rep. 2018 Sep 17;8(1):13938. doi: 10.1038/s41598-018-32044-7.

DOI:10.1038/s41598-018-32044-7
PMID:30224683
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6141549/
Abstract

In this study, we report on the fabrication of multilayered tri-functional magnetic-SERS-fluorescence nanoprobes (MF-SERS particles) containing clustered superparamagnetic FeO nanoparticles (NPs), silver NPs, and a fluorescent silica layer. The MF-SERS particles exhibited strong SERS signals from the silver NPs as well as both superparamagnetism and fluorescence. MF-SERS particles were uptaken by cells, allowing successful separation using an external magnetic field. SERS and fluorescence signals could be detected from the NP-containing cells, and CD44 antibody-conjugated MF-SERS particles selectively targeted MDA-MB-231 cells. Based on these properties, MF-SERS particles proved to be a useful nanoprobe for multiplex detection and separation of cancer cells.

摘要

在这项研究中，我们报告了多层三功能磁性表面增强拉曼散射-荧光纳米探针（MF-SERS 粒子）的制备，该探针包含聚集的超顺磁 FeO 纳米粒子（NPs）、银 NPs 和荧光二氧化硅层。MF-SERS 粒子表现出银 NPs 的强表面增强拉曼散射信号以及超顺磁性和荧光性。MF-SERS 粒子被细胞摄取，使用外部磁场可以成功分离。可以从含有 NP 的细胞中检测到 SERS 和荧光信号，并且 CD44 抗体偶联的 MF-SERS 粒子选择性地靶向 MDA-MB-231 细胞。基于这些特性，MF-SERS 粒子被证明是一种用于癌症细胞的多重检测和分离的有用纳米探针。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8404/6141549/b0c86f4ab241/41598_2018_32044_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8404/6141549/f6c8d95899a7/41598_2018_32044_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8404/6141549/56b21a0dfb07/41598_2018_32044_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8404/6141549/11c17847229f/41598_2018_32044_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8404/6141549/17b801eeb16c/41598_2018_32044_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8404/6141549/b0c86f4ab241/41598_2018_32044_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8404/6141549/f6c8d95899a7/41598_2018_32044_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8404/6141549/56b21a0dfb07/41598_2018_32044_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8404/6141549/11c17847229f/41598_2018_32044_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8404/6141549/17b801eeb16c/41598_2018_32044_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8404/6141549/b0c86f4ab241/41598_2018_32044_Fig5_HTML.jpg

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