Mori H, Tomonaga M, Baba N, Kanaya K
Acta Neuropathol. 1986;71(1-2):32-7. doi: 10.1007/BF00687959.
To clarify the structure of Hirano bodies, electron micrographs of Hirano bodies taken at various tilting angles have been studied by digital image analysis. On the electron micrographs, the beaded filaments of Hirano bodies were turned into a pattern of lattice-like arrays by changing the tilting angles. Based on computer-processed diffraction patterns and filtered images, it is proposed that the filaments of Hirano bodies are helical strands with a pitch of 185 A. A model for the helical strand drawn by microcomputer at various angles of rotation is in accordance with the filtered images of the tilted filaments. Computer simulation also reveals that the helical strands appear to be lattice-like when they are arranged in parallel.
为阐明 Hirano 小体的结构，通过数字图像分析研究了在不同倾斜角度下拍摄的 Hirano 小体的电子显微照片。在电子显微照片上，通过改变倾斜角度，Hirano 小体的串珠状细丝变成了晶格状排列的图案。基于计算机处理的衍射图案和滤波图像，提出 Hirano 小体的细丝是螺距为 185 Å 的螺旋链。由微型计算机在不同旋转角度绘制的螺旋链模型与倾斜细丝的滤波图像一致。计算机模拟还显示，当螺旋链平行排列时，它们看起来呈晶格状。
