Abdel-Naby Awad Osama G, Hamad Abdel-Monem H
Otolaryngology, Head and Neck Department, Minia University Hospital, Minia, Egypt.
Otolaryngology, Head and Neck Department, Minia University Hospital, Minia, Egypt.
Am J Otolaryngol. 2018 Nov-Dec;39(6):759-763. doi: 10.1016/j.amjoto.2018.09.007. Epub 2018 Sep 12.
Herpes simplex gingivostomatitis (HSGS) in children is a common painful infectious disease. This study aims to examine the combined efficacy of honey with acyclovir suspension compared to acyclovir alone for treating HSGS in young children.
This Randomized double blind placebo controlled study was conducted from June 2015 to September 2017 in a tertiary referral hospital. One hundred children aged 2-8 years with HSGS were randomly classified into 2 groups; study group: treated with honey plus oral acyclovir and control group: treated with oral acyclovir alone. Severity of oral lesions, Fever, eating and drinking ability, pain scores and need for analgesics were compared between 2 groups on day 3, 5 and 7 after starting treatment.
Children receiving honey plus acyclovir (i.e. study group) had significantly earlier disappearance of herpetic oral lesions; median 3 days vs. 6 days in control group (P = 0.022), drooling; 2 days vs. 4 days (P = 0.030) and eating difficulty; 3 days vs. 8 days (P = 0.001). Study group also had significantly lower pain scores, better eating and drinking ability and significantly less need for analgesics at 3 time-points of assessment. Fever disappeared in both groups with no statistically significant difference.
The combined use of honey with oral acyclovir can produce favorable outcome than acyclovir alone in children with Primary herpetic gingivostomatitis.
儿童单纯疱疹性龈口炎（HSGS）是一种常见的疼痛性传染病。本研究旨在检验蜂蜜与阿昔洛韦混悬液联合使用相较于单独使用阿昔洛韦治疗幼儿HSGS的综合疗效。
本随机双盲安慰剂对照研究于2015年6月至2017年9月在一家三级转诊医院进行。100名2 - 8岁患有HSGS的儿童被随机分为两组；研究组：接受蜂蜜加口服阿昔洛韦治疗，对照组：仅接受口服阿昔洛韦治疗。在开始治疗后的第3天、第5天和第7天，比较两组的口腔病变严重程度、发热情况、进食和饮水能力、疼痛评分以及对镇痛药的需求。
接受蜂蜜加阿昔洛韦治疗的儿童（即研究组）疱疹性口腔病变消失明显更早；中位数为3天，而对照组为6天（P = 0.022），流口水情况；2天对4天（P = 0.030）以及进食困难；3天对8天（P = 0.001）。研究组在3个评估时间点的疼痛评分也显著更低，进食和饮水能力更好，对镇痛药的需求显著更少。两组发热均消失，无统计学显著差异。
对于原发性疱疹性龈口炎患儿，蜂蜜与口服阿昔洛韦联合使用比单独使用阿昔洛韦能产生更好的效果。
