Toon P G, Arrand J R, Wilson L P, Sharp D S
Br Med J (Clin Res Ed). 1986 Nov 15;293(6557):1261-4. doi: 10.1136/bmj.293.6557.1261.
One hundred and six patients were studied whose cervical smears showed only non-specific inflammatory changes. Screening for genital pathogens yielded only a few positive cases. Histological examination of biopsy specimens taken by colposcopically directed tissue sampling showed cervical intraepithelial neoplasia in 13 of the women (12.3%). Deoxyribonucleic acid (DNA) hybridisation techniques were used to detect human papillomavirus, which was found in 24 patients (22.6%). In a second group of 104 patients with normal cervical cytology tissue biopsy samples were obtained and examined histologically but in no case was cervical intraepithelial neoplasia found. On DNA hybridisation, however, 12 patients (11.5%) were found to be positive for human papillomavirus. In this group finding human papillomavirus DNA was usually associated with a columnar ectopy. An association between human papillomavirus type 16 DNA and both cervical intraepithelial neoplasia and cervical cancer is well established. In this study it was type 16 which occurred most frequently in both groups.
对106例宫颈涂片仅显示非特异性炎症改变的患者进行了研究。对生殖道病原体的筛查仅发现少数阳性病例。通过阴道镜引导下组织取样获取的活检标本进行组织学检查，发现13名女性（12.3%）患有宫颈上皮内瘤变。采用脱氧核糖核酸（DNA）杂交技术检测人乳头瘤病毒，在24例患者（22.6%）中检测到该病毒。在第二组104例宫颈细胞学正常的患者中，获取组织活检样本并进行组织学检查，但未发现宫颈上皮内瘤变病例。然而，在DNA杂交检测中，发现12例患者（11.5%）人乳头瘤病毒呈阳性。在该组中，检测到人乳头瘤病毒DNA通常与柱状上皮异位有关。人乳头瘤病毒16型DNA与宫颈上皮内瘤变和宫颈癌之间的关联已得到充分证实。在本研究中，16型在两组中出现的频率最高。
