Cheetham D, Smith J, Wilson C, Munday P E, Coleman D V
Br J Vener Dis. 1984 Jun;60(3):182-5. doi: 10.1136/sti.60.3.182.
A group of 25 controls and 30 women with lesions of the cervix associated with papillomavirus were studied prospectively by colposcopy and cytology for up to two years to investigate the relation between human papillomavirus (HPV) infection of the cervix and resolution or progression of cervical intraepithelial neoplasia (CIN). We found that the viral changes were transient and that active infection, as judged by repeated colposcopic and cytological examination, resolved in 83% of the patients. Resolution or persistence of the viral infection did not appear to affect the development of the CIN lesion. The proportion of CIN lesions that resolved and persisted were the same for the study group and the controls. Possible reactivation of latent papillomavirus was noted in three control group patients. Our findings indicate that changes in the cervix associated with papillomavirus should not influence the clinical management or follow up of patients with CIN.
对25名对照者和30名患有与乳头瘤病毒相关的宫颈病变的女性进行了前瞻性研究，通过阴道镜检查和细胞学检查持续观察长达两年，以研究宫颈人乳头瘤病毒（HPV）感染与宫颈上皮内瘤变（CIN）的消退或进展之间的关系。我们发现病毒变化是短暂的，通过反复的阴道镜检查和细胞学检查判断，83%的患者的活动性感染得到了解决。病毒感染的消退或持续似乎并未影响CIN病变的发展。研究组和对照组中CIN病变消退和持续的比例相同。在三名对照组患者中发现了潜伏乳头瘤病毒可能的重新激活。我们的研究结果表明，与乳头瘤病毒相关的宫颈变化不应影响CIN患者的临床管理或随访。
